n -溴- n -呋喃苯磺酰酰胺（BFBSA）是一种新开发的在温和条件下溴化（Het）芳烃、药物和天然产物的试剂

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-05-13 DOI:10.1016/j.tet.2025.134723

Chaolin Li, Xianjin Yang

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引用次数: 0

摘要

报道了一种新开发的溴化试剂n -溴- n -呋喃苯磺酰酰胺（BFBSA），用于（Het）芳烃、药物和天然产物的高选择性和高效率溴化。该方案在温和条件下进行，具有底物范围广、功能基团耐受性好等特点，拓宽了复杂分子后期修饰的方法。它具有易得性好、成本低、对空气和水分不敏感等特点，在药物开发中具有潜在的应用前景。

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N-Bromo-N-fuorobenzenesulfonylamide (BFBSA) – A newly developed reagent for the bromination of (Het)arenes, drugs and natural products under mild conditions

A newly developed brominating reagent N-bromo-N-fuorobenzenesulfonylamide (BFBSA) for the bromination of (Het)arenes, drugs and natural products in high selectivity and efficiency is reported. This versatile protocol was conducted under mild conditions with the characteristics of wide substrates scope and excellent functional group tolerance, broadening the methodologies of the late-stage modification of complex molecules. The characteristics like ready availability, low cost and unsensitivity to air and moisture exhibit the potential applications in drug discovery.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.