双模镧掺杂UCNPs生物传感器通过nir响应上转换实现心肌损伤标志物的超灵敏定量

IF 4.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Colloids and Surfaces A: Physicochemical and Engineering Aspects Pub Date : 2025-05-22 DOI:10.1016/j.colsurfa.2025.137283

Yuemei Li , Yongmei Li , Rui Wang

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引用次数: 0

摘要

心脏病严重威胁着人类的生命和健康。研制一种检测急性心肌梗死的传感探针仍然是一个挑战。本文通过溶胶-凝胶法制备Yb3 +、Er3+和Al3+离子共掺杂ZnO （Yb/Er/AZO）上转换发光纳米粒子（UCNPs），该纳米粒子对ANP和cTnI抗原具有良好的检测灵敏度。获得了Yb/Er/ZnO的多色车削。在不同的激光功率下，Yb/Er/ZnO的UCL颜色由红色、白色到绿色变化。通过掺杂Al3+离子，观察到Yb/Er/AZO的纯红色UCL，实现了ANP和cTnI抗原的生物标记。Yb/Er/AZO-LFS对ANP和cTnI抗原的特异性检出限低于临床临界值，提高了检测灵敏度。此外，基于521/542 nm的Er3+离子强度比，Yb/Er/AZO UCNPs的最大相对温度灵敏度（SR）达到1.53 % K−1，实现了双模UCL探针和温度传感。

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Dual-mode lanthanide-doped UCNPs biosensor enables ultrasensitive quantification of myocardial injury markers via NIR-responsive upconversion

The heart disease poses a serious threat to human life and health. It is still a challenge to develop a sensing probe for detecting acute myocardial infarction. Herein, Yb^3 +, Er³⁺ and Al³⁺ ions co-doped ZnO (Yb/Er/AZO) upconversion luminescent nanoparticles (UCNPs) are prepared via sol-gel method, which has a good test sensitivity of ANP and cTnI antigens. The multi-color turning of Yb/Er/ZnO was obtained. The UCL color of Yb/Er/ZnO change from red, white to green with different laser power. The pure red UCL of Yb/Er/AZO is observed with Al³⁺ ions doping, which realizes ANP and cTnI antigens biomarkers. The specific detection limits for ANP and cTnI antigens in Yb/Er/AZO-LFS are lower than that of clinical critical values, which improve the detecting sensitivity. In addition, the maximum relatively temperature sensitivities (S_R) based on intensity ratio of 521/542 nm of Er³⁺ ions achieve 1.53 % K⁻¹ for Yb/Er/AZO UCNPs, realizing dual-mode UCL probe and temperature sensing.

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来源期刊

Colloids and Surfaces A: Physicochemical and Engineering Aspects 化学-物理化学

CiteScore

8.70

自引率

9.60%

发文量

2421

审稿时长

56 days

期刊介绍： Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.