由2-羟基环丁酮和含羧胺的Wittig试剂合成β- n -杂环-环丁烷-融合双环γ-内酯

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-05-26 DOI:10.1002/ejoc.202500332

Stefano Barranco, Mauro Uras, Veronica Frau, Pierluigi Caboni, Régis Guillot, David J. Aitken, Angelo Frongia

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引用次数: 0

摘要

建立了一个级联反应，可以在一次操作中以中等到较高的收率获得结构多样的2-恶沙环[3.2.0]庚烷-3-酮，在桥头堡的第四中心含有苯并[d]恶唑-2(3H)- 1片段。该反应说明了2-羟基环丁酮作为底物快速制备不寻常和复杂分子框架的潜力。

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Synthesis of β-N-Heterocyclic-Cyclobutane-Fused Bicyclic γ-Lactones from 2-Hydroxycyclobutanone and Carboxamide-Bearing Wittig Reagents

A cascade reaction has been established that enables access to structurally diverse 2-oxabicyclo[3.2.0]heptan-3-ones bearing a benzo[d]oxazol-2(3H)-one moiety at the bridgehead quaternary center in moderate to good yields in a single operation. The reaction illustrates the potential of 2-hydroxycyclobutanone as a substrate for the rapid preparation of unusual and complex molecular frameworks.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.