糖萼:治疗重症急性胰腺炎相关多器官功能障碍综合征的关键靶点。

IF 3.4 3区 生物学 Q3 CELL BIOLOGY
Huijuan Li, Haiyun Wen, Jie Liu, Xinyu Luo, Boliang Pei, Peng Ge, Zhenxuan Sun, Jin Liu, Junjie Wang, Hailong Chen
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引用次数: 0

摘要

内皮糖萼是由蛋白聚糖和糖胺聚糖组成的动态刷状层,包括硫酸肝素(HS)和透明质酸(HA),是血管稳态的重要调节因子。它的结构(不同物种的厚度从20到6450 nm不等)不仅提供了一个电荷选择屏障,而且还用于锚定机械传感器,如glypican-1 (GPC-1)/ cavo -1 (CAV-1)复合物,并缓冲剪切应力。在严重急性胰腺炎(SAP)中,炎症因子促进基质金属蛋白酶(MMPs)和肝素酶的表达,降解syndecan-1 (SDC-1)和HS,而氧化应激破坏HA-CD44的结合,导致毛细血管渗漏和中性粒细胞粘附增加。这种降解过程发生在多器官功能障碍综合征(MODS)发病之前,突出了糖萼作为早期生物标志物的潜力。更重要的是,通过内皮细胞合成糖胺聚糖(GAGs)和剪切应力驱动的SDC循环再生糖萼提供了治疗前景。本综述通过探讨糖盏的中心机制作用,重新定义了严重急性胰腺炎相关多器官功能障碍(SAP-MODS)的病理生理学,并提出稳定糖盏结构作为预防微循环衰竭的潜在策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The glycocalyx: a key target for treatment of severe acute pancreatitis-associated multiple organ dysfunction syndrome.

The endothelial glycocalyx is a dynamic brush-like layer composed of proteoglycans and glycosaminoglycans, including heparan sulfate (HS) and hyaluronic acid (HA), and is an important regulator of vascular homeostasis. Its structure (thickness ranges from 20 to 6450 nm in different species) not only provides a charge-selective barrier but also serves to anchor mechanosensors such as the glypican-1 (GPC-1)/caveolin-1 (CAV-1) complex and buffers shear stress. In severe acute pancreatitis (SAP), inflammatory factors promote the expression of matrix metalloproteinases (MMPs) and heparinases, which degrade syndecan-1 (SDC-1) and HS, while oxidative stress disrupts HA-CD44 binding, leading to increased capillary leakage and neutrophil adhesion. This degradation process occurs before the onset of multiple organ dysfunction syndrome (MODS), highlighting the potential of the glycocalyx as an early biomarker. More importantly, the regeneration of glycocalyx through endothelial cell synthesis of glycosaminoglycans (GAGs) and shear stress-driven SDC recycling provides therapeutic prospects. This review redefines the pathophysiology of severe acute pancreatitis-associated multiple organ dysfunction (SAP-MODS) by exploring the glycocalyx's central mechanistic role and proposes stabilizing glycocalyx structure as a potential strategy to prevent microcirculatory failure.

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来源期刊
Human Cell
Human Cell CELL BIOLOGY-
CiteScore
5.90
自引率
2.30%
发文量
176
审稿时长
4.5 months
期刊介绍: Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.
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