^ b{18} f -氟脱氧葡萄糖细胞摄取的扩散感知室模型。

IF 2.4 3区 物理与天体物理 Q1 Mathematics
Xiaoxu Zhong, Hieu T M Nguyen, Eri Takematsu, Guillem Pratx
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引用次数: 0

摘要

隔间模型广泛应用于流行病学和生物医学等领域,用于描述相互连接的隔间之间均匀分布的物质交换。然而,它们在生物流体中的应用受到无限大扩散假设的限制,特别是在扩散相当低的肿瘤或皮下组织等环境中。为了解决这个问题,我们开发了一个扩散感知的隔间模型,它保持了传统隔间模型的简单性,同时提供了更高的准确性。我们对培养板中生长的细胞对放射性核素氟脱氧葡萄糖(FDG)的吸收进行了实验,发现测量的细胞放射性与预测的细胞放射性之间有很好的一致性。我们确定了两个关键的无量纲参数,用于比较(i)通过扩散补充的FDG量和(ii)培养基中可用的FDG量与细胞吸收的FDG量。我们证明,当FDG扩散相对于细胞摄取快时,扩散感知室模型可简化为三室模型,当培养液中有足够的FDG时,可进一步简化为两室模型。扩散感知室模型的半解析解可以很容易地扩展到研究其他场景,如药物运输和气泡生长动力学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diffusion-aware compartment model of the cellular uptake of ^{18}F-fluorodeoxyglucose.

Compartment models are widely used in fields such as epidemiology and biomedicine to describe the exchange of uniformly distributed materials between interconnected compartments. However, their application in biological fluids is limited by the assumption of infinitely large diffusivity, especially in environments such as tumors or subcutaneous tissue, where diffusion is considerably lower. To address this, we develop a diffusion-aware compartment model that maintains the simplicity of traditional compartment models while offering greater accuracy. We conducted experiments on the uptake of ^{18}F-fluorodeoxyglucose (FDG), a radionuclide, by cells grown in culture plates and found a good agreement between the measured and predicted cellular radioactivity. We identify two critical dimensionless parameters that compare the amount of FDG (i) replenished by diffusion and (ii) available in the culture medium to the amount of FDG taken up by cells. We demonstrate that the diffusion-aware compartment model reduces to the three-compartment model when FDG diffusion is fast relative to cellular uptake, and it further simplifies to the two-compartment model when sufficient FDG is available in the culture medium. The semianalytic solutions of the diffusion-aware compartment model can be easily extended to study other scenarios, such as drug transport and bubble growth dynamics.

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来源期刊
Physical review. E
Physical review. E 物理-物理:流体与等离子体
CiteScore
4.60
自引率
16.70%
发文量
0
审稿时长
3.3 months
期刊介绍: Physical Review E (PRE), broad and interdisciplinary in scope, focuses on collective phenomena of many-body systems, with statistical physics and nonlinear dynamics as the central themes of the journal. Physical Review E publishes recent developments in biological and soft matter physics including granular materials, colloids, complex fluids, liquid crystals, and polymers. The journal covers fluid dynamics and plasma physics and includes sections on computational and interdisciplinary physics, for example, complex networks.
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