区分斑块侵蚀和稳定斑块的生物标志物。

IF 5.7 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Teruo Sekimoto, Shiraki Tatsuya, Rika Kawakami, Atsushi Sakamoto, Takamasa Tanaka, Tomoyo Hamana, Aloke V Finn, Renu Virmani
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引用次数: 0

摘要

回顾目的:斑块侵蚀是急性冠脉综合征的第二大常见原因,然而与侵蚀相关的生物学过程和生物标志物仍不完全清楚。本综述旨在研究目前对斑块侵蚀的理解,重点是识别潜在的生物标志物。最近的发现:最近的研究已经确定了与斑块侵蚀相关的不同病理生理特征,包括罪魁祸首病变和血栓内炎症反应和免疫细胞浸润的变化。此外,已经注意到特定分子表达模式的差异,表明导致斑块侵蚀的独特潜在机制。了解免疫细胞和生物标志物在糜烂中的差异表达和作用可能对开发靶向治疗至关重要。生物标志物的鉴定可能有助于早期发现和治疗易腐蚀斑块,潜在地减少急性冠状动脉事件的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomarkers Differentiating Plaque Erosion from Stable Plaque.

Purpose of review: Plaque erosion is the second most frequent cause of acute coronary syndrome, yet the biological processes and biomarkers associated with erosion remain incompletely understood. This review aims to examine the current understanding of plaque erosion, with a focus on identifying potential biomarkers.

Recent findings: Recent studies have identified distinct pathophysiological characteristics associated with plaque erosion, including variations in inflammatory response and immune cell infiltration within the culprit lesions and thrombi. Additionally, differences in the expression patterns of specific molecules have been noted, suggesting unique underlying mechanisms that contribute to plaque erosion. Understanding the differential expression and role of immune cells and biomarkers in erosion may be crucial for developing targeted therapies. The identification of biomarkers may help in the early detection and treatment of erosion-prone plaques, potentially reducing the incidence of acute coronary events.

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来源期刊
CiteScore
9.00
自引率
3.40%
发文量
87
审稿时长
6-12 weeks
期刊介绍: The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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