{"title":"羟氯喹治疗外阴扁平地衣。","authors":"Harmony Thompson, Amanda Oakley, Harriet Kennedy","doi":"10.1097/LGT.0000000000000843","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Vulval lichen planus (VLP) is a chronic inflammatory dermatosis that is often refractory to treatment and results in poor quality of life. The management of recalcitrant disease is not well described in the current literature. Hydroxychloroquine (HCQ) has a role in treating oral and cutaneous lichen planus and may be used in VLP based on expert opinion. This review aimed at adding to the limited existing evidence on the role of HCQ for VLP.</p><p><strong>Materials and methods: </strong>This is a case series of 23 people with VLP treated with HCQ. Outcomes were assessed based on physician global assessment.</p><p><strong>Results: </strong>Twenty-three people with a mean age of 66 years were included. Ten patients (44%) had a much improved response to HCQ, 1 patient (4%) had a partial response, and 7 (30%) had minimal/no response to treatment. Five people (22%) experienced side effects that resulted in stopping HCQ.</p><p><strong>Conclusions: </strong>This series demonstrated some efficacy of HCQ in treating VLP. We are limited by the small participant numbers due to the rarity of this condition and a lack of an objective assessment tool. Further controlled studies are needed to assess the effectiveness and tolerability of HCQ in treating this complex condition.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"28 4","pages":"394-397"},"PeriodicalIF":2.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hydroxychloroquine for Vulval Lichen Planus.\",\"authors\":\"Harmony Thompson, Amanda Oakley, Harriet Kennedy\",\"doi\":\"10.1097/LGT.0000000000000843\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Vulval lichen planus (VLP) is a chronic inflammatory dermatosis that is often refractory to treatment and results in poor quality of life. The management of recalcitrant disease is not well described in the current literature. Hydroxychloroquine (HCQ) has a role in treating oral and cutaneous lichen planus and may be used in VLP based on expert opinion. This review aimed at adding to the limited existing evidence on the role of HCQ for VLP.</p><p><strong>Materials and methods: </strong>This is a case series of 23 people with VLP treated with HCQ. Outcomes were assessed based on physician global assessment.</p><p><strong>Results: </strong>Twenty-three people with a mean age of 66 years were included. Ten patients (44%) had a much improved response to HCQ, 1 patient (4%) had a partial response, and 7 (30%) had minimal/no response to treatment. Five people (22%) experienced side effects that resulted in stopping HCQ.</p><p><strong>Conclusions: </strong>This series demonstrated some efficacy of HCQ in treating VLP. We are limited by the small participant numbers due to the rarity of this condition and a lack of an objective assessment tool. Further controlled studies are needed to assess the effectiveness and tolerability of HCQ in treating this complex condition.</p>\",\"PeriodicalId\":50160,\"journal\":{\"name\":\"Journal of Lower Genital Tract Disease\",\"volume\":\"28 4\",\"pages\":\"394-397\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Lower Genital Tract Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/LGT.0000000000000843\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Lower Genital Tract Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/LGT.0000000000000843","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Objectives: Vulval lichen planus (VLP) is a chronic inflammatory dermatosis that is often refractory to treatment and results in poor quality of life. The management of recalcitrant disease is not well described in the current literature. Hydroxychloroquine (HCQ) has a role in treating oral and cutaneous lichen planus and may be used in VLP based on expert opinion. This review aimed at adding to the limited existing evidence on the role of HCQ for VLP.
Materials and methods: This is a case series of 23 people with VLP treated with HCQ. Outcomes were assessed based on physician global assessment.
Results: Twenty-three people with a mean age of 66 years were included. Ten patients (44%) had a much improved response to HCQ, 1 patient (4%) had a partial response, and 7 (30%) had minimal/no response to treatment. Five people (22%) experienced side effects that resulted in stopping HCQ.
Conclusions: This series demonstrated some efficacy of HCQ in treating VLP. We are limited by the small participant numbers due to the rarity of this condition and a lack of an objective assessment tool. Further controlled studies are needed to assess the effectiveness and tolerability of HCQ in treating this complex condition.
期刊介绍：
The Journal of Lower Genital Tract Disease is the source for the latest science about benign and malignant conditions of the cervix, vagina, vulva, and anus.
The Journal publishes peer-reviewed original research original research that addresses prevalence, causes, mechanisms, diagnosis, course, treatment, and prevention of lower genital tract disease. We publish clinical guidelines, position papers, cost-effectiveness analyses, narrative reviews, and systematic reviews, including meta-analyses. We also publish papers about research and reporting methods, opinions about controversial medical issues. Of particular note, we encourage material in any of the above mentioned categories that is related to improving patient care, avoiding medical errors, and comparative effectiveness research. We encourage publication of evidence-based guidelines, diagnostic and therapeutic algorithms, and decision aids. Original research and reviews may be sub-classified according to topic: cervix and HPV, vulva and vagina, perianal and anal, basic science, and education and learning.
The scope and readership of the journal extend to several disciplines: gynecology, internal medicine, family practice, dermatology, physical therapy, pathology, sociology, psychology, anthropology, sex therapy, and pharmacology. The Journal of Lower Genital Tract Disease highlights needs for future research, and enhances health care.
The Journal of Lower Genital Tract Disease is the official journal of the American Society for Colposcopy and Cervical Pathology, the International Society for the Study of Vulvovaginal Disease, and the International Federation of Cervical Pathology and Colposcopy, and sponsored by the Australian Society for Colposcopy and Cervical Pathology and the Society of Canadian Colposcopists.
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