小檗（Vulgaris和Integerrima）对2型糖尿病患者心血管危险因素的影响：系统回顾、meta分析和GRADE评估

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Therapeutic Research-clinical and Experimental Pub Date : 2025-01-01 DOI:10.1016/j.curtheres.2025.100788

Vali Musazadeh , Niloofar Hamidi , Morvarid Noormohammadi , Farzad Shidfar

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引用次数: 0

摘要

2型糖尿病（T2DM）增加心血管疾病风险，但小檗影响的证据有限且不一致。本系统综述和荟萃分析旨在评估小檗补充剂对T2DM患者心血管危险因素的影响。材料与方法我们广泛检索Embase、Web of Science、Scopus、PubMed、Cochrane Library，检索截止到2024年10月25日的随机对照试验（RCTs）。本研究主要评估了小檗对改善血糖指数的影响，次要指标包括肥胖、血压和血脂参数。研究结果：在回顾了784篇文章后，我们纳入了8项随机对照试验的数据，涉及451名T2DM患者。meta分析结果显示，小檗治疗组体重显著降低(WMD: -2.25；95% CI: -3.11 ~ -1.39)，体重指数(BMI, WMD: -0.57；95% CI: -0.98 ~ -0.17), TG (WMD: -19.32；95% CI: -30.95 ~ -1.69), TC (WMD: -28.57；95% CI: -30.22 ~ -21.51), LDL-C (WMD: -17.47；95% CI: -24.18 ~ -10.75), FBS (WMD: -14.54；95% CI: -23.83, -5.25), HbA1c (WMD: -0.65；95% ci: -1.30, -0.00), homa-ir (wmd: -1.82；95% CI: -3.60, -0.05)和胰岛素(WMD: -4.40；95% ci: -7.15, -1.65)。然而，小檗干预对血压和HDL-C水平没有统计学意义上的显著影响。结论：本荟萃分析提示小檗对2型糖尿病的潜在益处。然而，需要更广泛的试验来确定其优势。

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The Effect of Berberis (Vulgaris and Integerrima) on Cardiovascular Risk Factors in Patients With Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and GRADE Assessment

Introduction and Aim

Type 2 diabetes mellitus (T2DM) raises cardiovascular disease risk, but evidence on Berberis's impact is limited and inconsistent. This systematic review and meta-analysis aimed to assess effect of Berberis supplement on cardiovascular risk factors in patients with T2DM.

Materials and Methods

We extensively searched Embase, Web of Science, Scopus, PubMed, and the Cochrane Library for randomized controlled trials (RCTs) up to October 25, 2024. This study primarily assesses Berberis's impact on improving glycemic indices, with secondary measures including obesity, blood pressure and lipid profile parameters.

Findings

After reviewing 784 articles, we included data from eight RCTs involving 451 participants with T2DM. The results of meta-analysis indicated that Berberis administration significantly reduced weight (WMD: -2.25; 95% CI: -3.11 to -1.39), body mass index (BMI, WMD: -0.57; 95% CI: -0.98 to -0.17), TG (WMD: -19.32; 95% CI: -30.95 to -1.69), TC (WMD: -28.57; 95% CI: -30.22 to -21.51), LDL-C (WMD: -17.47; 95% CI: -24.18 to -10.75), FBS (WMD: -14.54; 95% CI: -23.83, -5.25), HbA1c (WMD: -0.65; 95% CI: -1.30, -0.00), HOMA-IR (WMD: -1.82; 95% CI: -3.60, -0.05), and insulin (WMD: -4.40; 95% CI: -7.15, -1.65). However, no statistically significant effect on blood pressure and HDL-C level was observed with Berberis intervention.

Conclusion

This meta-analysis hints at Berberis's potential benefits for T2DM. However, more extensive trials are needed to confirm its advantages definitively.

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来源期刊

Current Therapeutic Research-clinical and Experimental 医学-药学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

3 months

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