凝聚膜相互作用形成膜，调整细胞骨架组装，并定位mrna

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-05-26 DOI:10.1016/j.ceb.2025.102540

Wilton T. Snead

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引用次数: 0

摘要

生物分子凝聚体已成为亚细胞的重要组成部分。虽然冷凝物在没有分隔膜的情况下组织生物化学，但冷凝物在不同的细胞环境中经常与膜表面相互作用。冷凝物和膜相互调节，诱导膜形状改变，建立不同脂质组成的结构域，并催化冷凝物内的反应。在这里，我讨论了我们对凝聚物-膜界面的理解的最新进展，重点是膜形成，脂质组织，细胞骨架调节和mRNA运输。最后，我提出了可能揭示膜相关凝聚物新功能的研究途径，重点是RNA在凝聚物-膜界面中的未充分研究的作用。

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Condensate-membrane interactions shape membranes, tune cytoskeletal assembly, and localize mRNAs

Biomolecular condensates have emerged as essential subcellular compartments. Although condensates organize biochemistry without a delimiting membrane, condensates frequently interact with membrane surfaces in diverse cellular contexts. Condensates and membranes reciprocally modulate each other, inducing membrane shape changes, establishing domains of distinct lipid composition, and catalyzing reactions within condensates. Here I discuss recent advancements in our understanding of the condensate-membrane interface, with a focus on membrane shaping, lipid organization, cytoskeletal regulation, and mRNA transport. I conclude by suggesting research avenues that may uncover new functions for membrane-associated condensates, with emphasis on the understudied role of RNA in the condensate-membrane interface.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.