含方卡因水凝胶：合成、给药和双重光疗

IF 4.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Colloids and Surfaces A: Physicochemical and Engineering Aspects Pub Date : 2025-05-23 DOI:10.1016/j.colsurfa.2025.137290

Rumeysa Sarıgöl , Melek Pamuk Algi

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引用次数: 0

摘要

为了创建一个多用途的治疗平台，Sq@poly（HEMA-co-AA）水凝胶由2-羟乙基甲基丙烯酸酯（HEMA）和丙烯酸（AA）单体制成。用SK-MEL-30皮肤癌细胞株检测水凝胶的治疗效果。Sq@poly（HEMA-co-AA）水凝胶在红光下通过产生活性氧进行光动力治疗，在近红外光下通过产生热疗进行光热治疗。结果表明，水凝胶对皮肤癌具有抗癌潜力。此外，根据对L929细胞系进行的生物相容性测试，水凝胶在没有光的情况下不会产生毒性。在808 nm的激光照射下，罗丹明B以光响应的方式有效释放，证明了水凝胶具有光触发药物递送的能力。这些结果证明了Sq@poly（HEMA-co-AA）水凝胶作为一种柔性材料的药物控释和光治疗应用的有趣潜力，特别是在治疗皮肤癌方面。

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Squaraine-containing hydrogels: Synthesis, drug delivery and dual phototherapies

To create a multipurpose therapeutic platform, Sq@poly(HEMA-co-AA) hydrogels are made of 2-hydroxyethyl methacrylate (HEMA) and acrylic acid (AA) monomers. The SK-MEL-30 skin cancer cell line was used to test the hydrogels' therapeutic effectiveness. The Sq@poly(HEMA-co-AA) hydrogels demonstrated photodynamic therapy by producing reactive oxygen species under red light and photothermal therapy by producing hyperthermia under near-infrared light. The outcomes showed the anti-cancer potential of the hydrogels against skin cancer. Furthermore, the hydrogels did not cause toxicity in the absence of light, according to biocompatibility tests conducted on the L929 cell line. Rhodamine B was efficiently released in a light-responsive manner, following exposure to a laser at 808 nm, demonstrating the hydrogels' capability for light-triggered drug delivery. These results demonstrate the intriguing potential of Sq@poly(HEMA-co-AA) hydrogels as a flexible material for controlled release of drugs and phototherapeutic applications, especially in the treatment of skin cancer.

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来源期刊

Colloids and Surfaces A: Physicochemical and Engineering Aspects 化学-物理化学

CiteScore

8.70

自引率

9.60%

发文量

2421

审稿时长

56 days

期刊介绍： Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.