Faycel Djebbar, Lise-Marie Chamoreau and Guillaume Lefèvre*,
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Influence of a Two-Fold Ligation Pattern on Iron-Mediated Aryl–Heteroaryl Cross-Electrophile Couplings
An aryl–heteroaryl cross-electrophile coupling (XEC) relying on the use of a single, well-defined iron catalyst is disclosed, involving magnesium as an electron source as well as heteroaryl chlorides and aryl iodides or bromides as coupling partners. A 2-fold coordination pattern featuring a π-acceptor, redox-active (N,N) ligand, along with a σ-donating phosphine ensures both the two-electron reduction of the starting iron(II) precursor to enter the cycle and access to stable organoiron(II) resting states, inhibiting the reductive decomposition of the catalyst.
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