平滑肌肉瘤的治疗方法及未来发展方向。

IF 2.5 3区医学 Q2 HEMATOLOGY

Hematology-Oncology Clinics of North America Pub Date : 2025-05-22 DOI:10.1016/j.hoc.2025.04.007

Candace L Haddox, David J Papke, César Serrano

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引用次数: 0

摘要

平滑肌肉瘤（LMS）是平滑肌分化的间充质恶性肿瘤，最常见于子宫、腹膜后和四肢。临床病程多变，治疗因发病部位不同而不同。最近完成和正在进行的临床试验正在优化LMS管理，专家团队的多学科护理对于导航细微差别并提供最佳护理至关重要。分子表征的进步改善了诊断和识别新的预后因素和全身治疗。本文综述了LMS的表现、诊断、分子特征和临床管理，并重点介绍了LMS生物学和治疗方面的进展。

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Leiomyosarcoma Therapeutic Approaches and Future Directions.

Leiomyosarcomas (LMS) are mesenchymal malignancies with smooth muscle differentiation that most commonly arise in the uterus, retroperitoneum, and extremity. Clinical course is variable, and management differs by site of origin. Recently completed and ongoing clinical trials are optimizing LMS management, and multidisciplinary care by an expert team is essential to navigate the nuances and provide optimal care. Advances in molecular characterization have improved diagnosis and identification of novel prognostic factors and systemic therapies. This article provides an overview of LMS presentation, diagnosis, molecular features, and clinical management, and highlights advancements in LMS biology and treatment.

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来源期刊

Hematology-Oncology Clinics of North America 医学-血液学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.