Pedro M P Cunha, Ricardo J Ribeiro, Andreia Pizarro, Jorge Mota, Jose C D Ribeiro
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引用次数: 0
摘要
背景：本系统综述探讨了体育锻炼对慢性淋巴细胞白血病（CLL）患者身体健康、免疫和生活质量的影响。方法：到2024年2月，在PubMed和Web of Science中检索符合条件的研究，如果参与者为成年，确诊为CLL，使用具有研究设计的干预方案、临床试验或定量数据报告的体育活动方案，则纳入研究。使用Cochrane的robins - 1和RoB2工具评估偏倚。结果以表格和图表的形式呈现。定性综合描述了纳入研究的主要结果。由于异质性显著，未进行meta分析。结果：本综述共纳入92项研究，其中6项符合纳入标准，样本量为323例患者。这些研究主要集中在心血管训练结合抗阻训练（4项研究，共177例患者）、心血管持续训练（1项研究，共122例患者）和耐力抗阻训练（1项研究，共24例患者），强调了CLL患者治疗前体育锻炼的重要性，干预组的体质和免疫参数均有显著改善。讨论：关于运动对慢性淋巴细胞白血病影响的研究较少，在试点研究实验中，患者样本较少，注意到运动在改善身体健康和免疫参数方面起着至关重要的作用。然而，没有人提到力量训练，这是在体育活动干预中增加肌肉质量的最佳选择之一。干预和/或评估方案的不一致性，使得运动和医疗专业人员在规定不同的运动模式、提高对规定的运动计划的依从性以及确定在运动处方的背景下应该使用哪种干预措施方面提出了建议。需要更多的研究来评估体育活动对慢性淋巴细胞白血病患者健康相关生活质量和寿命的影响。试验注册：PROSPERO CRD42023464877。
High-intensity interval training and strength conditioning in patients with chronic lymphocytic leukemia: a systematic review.
Background: This systematic review explores the impact of physical exercise on chronic lymphocytic leukemia (CLL) patients' physical fitness, immunologic, and quality of life outcomes.
Methods: Eligible studies were searched in PubMed and Web of Science up to February 2024 and were included if they involved participants in adult age, with confirmed CLL diagnose, using physical activity protocols with study design helding intervention protocols, clinical trials, or quantitative data reporting. Bias was assessed with ROBINS-I and RoB2 tools from Cochrane. The results are presented in tables and figures. A qualitative synthesis describes the main outcomes of the included studies. Meta-analysis was not performed due to significant heterogeneity.
Results: This review identifies 92 studies, with 6 meeting the inclusion criteria, with a sample size of 323 patients. These studies focus on cardiovascular training combined with resistance training (four studies with total sample of 177 patients), continuous cardiovascular training (one study with 122 patients), and endurance resistance training (one study with 24 patients), highlighting the importance of physical exercise in CLL patients before treatment, with significant improvements in physical fitness and immunologic parameters on intervention groups.
Discussion: The paucity regarding exercise influence on CLL, with small samples of patients in pilot study experiments, noted that exercise plays a vital role in improving physical fitness and immunologic parameters. However, none addressed strength training, which is known as one of the best options to increase muscular mass in physical activity interventions. The inconsistency of intervention and/or evaluation protocols ravels the advice of exercise and medical professionals on prescribing different modes of exercise, improving compliance with the prescribed exercise program, and determining which intervention in the context of exercise prescription should be used. More studies are needed to evaluate the impact of physical activity on the health-related quality of life and life span of the CLL patient.
期刊介绍：
Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.
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