立体定向放疗在儿童和年轻人中的应用：我们能应用成人治疗模式吗？

IF 6.4 1区医学 Q1 ONCOLOGY

International Journal of Radiation Oncology Biology Physics Pub Date : 2025-05-21 DOI:10.1016/j.ijrobp.2025.05.011

Derek S Tsang, Erin Murphy, Kilian E Salerno, Jeannette Parkes, Susan M Hiniker, Steve Braunstein

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引用次数: 0

摘要

立体定向放射治疗（RT）在儿童和青少年恶性肿瘤和良性疾病的治疗中的应用一直在增加。然而，与成人数据相比，在这一人群中指导立体定向放疗的证据尚处于起步阶段。在这篇重要的综述中，作者讨论了立体定向放射治疗（SBRT）和立体定向放射手术（SRS）背后的一些成人证据，以及如何将其应用于患有癌症的儿童。综述了SBRT和SRS的儿科特异性证据和指南，包括适应症、治疗方法、结果和未来的研究方向。

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Stereotactic radiotherapy in children and young adults: Can we apply adult treatment paradigms?

The use of stereotactic radiation therapy (RT) in the treatment of children and young adults with malignancies and benign conditions has been increasing. However, the evidence guiding stereotactic RT in this population is in a nascent phase as compared to adult-derived data. In this critical review, the authors discuss some of the adult evidence behind stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS), and how it can be applied to children with cancer. An overview of pediatric-specific evidence and guidelines for SBRT and SRS are discussed, including indications, treatment approaches, outcomes, and future directions for research.

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来源期刊

International Journal of Radiation Oncology Biology Physics 医学-核医学

CiteScore

11.00

自引率

7.10%

发文量

2538

审稿时长

6.6 weeks

期刊介绍： International Journal of Radiation Oncology • Biology • Physics (IJROBP), known in the field as the Red Journal, publishes original laboratory and clinical investigations related to radiation oncology, radiation biology, medical physics, and both education and health policy as it relates to the field. This journal has a particular interest in original contributions of the following types: prospective clinical trials, outcomes research, and large database interrogation. In addition, it seeks reports of high-impact innovations in single or combined modality treatment, tumor sensitization, normal tissue protection (including both precision avoidance and pharmacologic means), brachytherapy, particle irradiation, and cancer imaging. Technical advances related to dosimetry and conformal radiation treatment planning are of interest, as are basic science studies investigating tumor physiology and the molecular biology underlying cancer and normal tissue radiation response.