表面增强拉曼散射（SERS）技术：在癌症成像和精准医学中的新兴应用。

IF 4.3 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Methods Pub Date : 2025-05-21 DOI:10.1016/j.ymeth.2025.05.009

Biqing Chen, Jiayin Gao, Haizhu Sun, Zhi Chen, Xiaohong Qiu

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引用次数: 0

摘要

表面增强拉曼散射（SERS）生物探针的最新进展大大增强了其在疾病治疗中的生物成像能力。本文系统分析了三种工程SERS探针：贵金属纳米结构、金属氧化物杂化物和多功能复合材料，重点介绍了它们在靶向肿瘤检测和图像引导手术中的优化设计。主要发展包括改进的体外生物传感平台，用于快速肿瘤筛查和先进的体内探针，实现具有分子特异性的实时术中成像。SERS与互补模式（荧光，光声，MRI）的整合被严格检查为克服个人技术限制和实现多尺度组织表征的策略。在空间分辨率增强、多重生物标志物检测和生物相容性优化等方面的技术进步得到了定量的强调。讨论了生物系统和可扩展探针制造中信号一致性的当前挑战，提出了标准化评估框架，作为临床翻译的必要条件。这项工作建立了SERS作为精确肿瘤学的多模态成像基石，特别是在肿瘤边缘划定和转移灶识别方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Surface-enhanced Raman scattering (SERS) technology: Emerging applications in cancer imaging and precision medicine

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Surface-enhanced Raman scattering (SERS) technology: Emerging applications in cancer imaging and precision medicine

Recent advancements in Surface-enhanced Raman Scattering (SERS) bioprobes have substantially enhanced their bioimaging capabilities for disease theranostics. This review systematically analyzes three categories of engineered SERS probes: noble metal nanostructures, metal oxide hybrids, and multifunctional composite materials, emphasizing their optimized designs for targeted tumor detection and image-guided surgery. Key developments include improved in vitro biosensing platforms for rapid tumor screening and advanced in vivo probes enabling real-time intraoperative imaging with molecular specificity. The integration of SERS with complementary modalities (fluorescence, photoacoustic, MRI) is critically examined as a strategy to overcome individual technical limitations and achieve multiscale tissue characterization. Technical progress in spatial resolution enhancement, multiplex biomarker detection, and biocompatibility optimization is quantitatively highlighted. Current challenges in signal consistency across biological systems and scalable probe manufacturing are discussed, proposing standardized evaluation frameworks as essential for clinical translation. This work establishes SERS as a multimodal imaging cornerstone for precision oncology, particularly in tumor margin delineation and metastatic lesion identification.

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来源期刊

Methods 生物-生化研究方法

CiteScore

9.80

自引率

2.10%

发文量

222

审稿时长

11.3 weeks

期刊介绍： Methods focuses on rapidly developing techniques in the experimental biological and medical sciences. Each topical issue, organized by a guest editor who is an expert in the area covered, consists solely of invited quality articles by specialist authors, many of them reviews. Issues are devoted to specific technical approaches with emphasis on clear detailed descriptions of protocols that allow them to be reproduced easily. The background information provided enables researchers to understand the principles underlying the methods; other helpful sections include comparisons of alternative methods giving the advantages and disadvantages of particular methods, guidance on avoiding potential pitfalls, and suggestions for troubleshooting.