{"title":"启用化学全息术:一个全面的框架和实施","authors":"Shihao Ran;David Mayerich;Rohith Reddy","doi":"10.1109/JPHOT.2025.3567016","DOIUrl":null,"url":null,"abstract":"Mid-infrared spectroscopic imaging (MIRSI) enables the spatially-resolved identification of molecules and is widely used in fields ranging from biomedical diagnostics to forensics. Current MIRSI technologies measure the sample's extinction coefficient, which is only one component of the complex relative permittivity, and therefore provide incomplete molecular profiles. We propose a new framework and instrument to enable phase-sensitive <italic>chemical holography</i> that measures a sample's <italic>complex</i> molecular properties at any wavelength, thus overcoming a fundamental limit on molecular specificity. Combining a spatially coherent quantum cascade laser (QCL) source with an interferometer and imaging system can provide a phase-sensitive platform for molecular analysis. This paper describes a theoretical framework for chemical holography and demonstrates benefits for molecular specificity, improved spatial resolution, and greater flexibility. Deep learning is used to solve the inverse scattering problem for chemically heterogeneous samples modeled using Mie theory. Furthermore, we demonstrate new, custom-built instrumentation and experimental results that validate our theoretical framework.","PeriodicalId":13204,"journal":{"name":"IEEE Photonics Journal","volume":"17 3","pages":"1-11"},"PeriodicalIF":2.4000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10985816","citationCount":"0","resultStr":"{\"title\":\"Enabling Chemical Holography: A Comprehensive Framework and Implementation\",\"authors\":\"Shihao Ran;David Mayerich;Rohith Reddy\",\"doi\":\"10.1109/JPHOT.2025.3567016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Mid-infrared spectroscopic imaging (MIRSI) enables the spatially-resolved identification of molecules and is widely used in fields ranging from biomedical diagnostics to forensics. Current MIRSI technologies measure the sample's extinction coefficient, which is only one component of the complex relative permittivity, and therefore provide incomplete molecular profiles. We propose a new framework and instrument to enable phase-sensitive <italic>chemical holography</i> that measures a sample's <italic>complex</i> molecular properties at any wavelength, thus overcoming a fundamental limit on molecular specificity. Combining a spatially coherent quantum cascade laser (QCL) source with an interferometer and imaging system can provide a phase-sensitive platform for molecular analysis. This paper describes a theoretical framework for chemical holography and demonstrates benefits for molecular specificity, improved spatial resolution, and greater flexibility. Deep learning is used to solve the inverse scattering problem for chemically heterogeneous samples modeled using Mie theory. Furthermore, we demonstrate new, custom-built instrumentation and experimental results that validate our theoretical framework.\",\"PeriodicalId\":13204,\"journal\":{\"name\":\"IEEE Photonics Journal\",\"volume\":\"17 3\",\"pages\":\"1-11\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10985816\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE Photonics Journal\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://ieeexplore.ieee.org/document/10985816/\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Photonics Journal","FirstCategoryId":"5","ListUrlMain":"https://ieeexplore.ieee.org/document/10985816/","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Enabling Chemical Holography: A Comprehensive Framework and Implementation
Mid-infrared spectroscopic imaging (MIRSI) enables the spatially-resolved identification of molecules and is widely used in fields ranging from biomedical diagnostics to forensics. Current MIRSI technologies measure the sample's extinction coefficient, which is only one component of the complex relative permittivity, and therefore provide incomplete molecular profiles. We propose a new framework and instrument to enable phase-sensitive chemical holography that measures a sample's complex molecular properties at any wavelength, thus overcoming a fundamental limit on molecular specificity. Combining a spatially coherent quantum cascade laser (QCL) source with an interferometer and imaging system can provide a phase-sensitive platform for molecular analysis. This paper describes a theoretical framework for chemical holography and demonstrates benefits for molecular specificity, improved spatial resolution, and greater flexibility. Deep learning is used to solve the inverse scattering problem for chemically heterogeneous samples modeled using Mie theory. Furthermore, we demonstrate new, custom-built instrumentation and experimental results that validate our theoretical framework.
期刊介绍:
Breakthroughs in the generation of light and in its control and utilization have given rise to the field of Photonics, a rapidly expanding area of science and technology with major technological and economic impact. Photonics integrates quantum electronics and optics to accelerate progress in the generation of novel photon sources and in their utilization in emerging applications at the micro and nano scales spanning from the far-infrared/THz to the x-ray region of the electromagnetic spectrum. IEEE Photonics Journal is an online-only journal dedicated to the rapid disclosure of top-quality peer-reviewed research at the forefront of all areas of photonics. Contributions addressing issues ranging from fundamental understanding to emerging technologies and applications are within the scope of the Journal. The Journal includes topics in: Photon sources from far infrared to X-rays, Photonics materials and engineered photonic structures, Integrated optics and optoelectronic, Ultrafast, attosecond, high field and short wavelength photonics, Biophotonics, including DNA photonics, Nanophotonics, Magnetophotonics, Fundamentals of light propagation and interaction; nonlinear effects, Optical data storage, Fiber optics and optical communications devices, systems, and technologies, Micro Opto Electro Mechanical Systems (MOEMS), Microwave photonics, Optical Sensors.