脂滴的新参与者：它们的调节和功能

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-05-24 DOI:10.1016/j.ceb.2025.102541

Huimin Pan , Honggang Su , Xun Huang

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引用次数: 0

摘要

脂滴（ld）是一种高度保守的细胞器，广泛存在于原核生物和真核生物中。LD蛋白是一组与LD相关的蛋白质，调节LD功能的各个方面，如储存、动员和与其他细胞器的相互作用。最近对LD蛋白的研究揭示了LD蛋白在生理和病理方面的更广泛的作用，超出了它们在脂质代谢中的传统功能。在这篇综述中，我们总结了LD蛋白靶向背后的机制，并探讨了LD上新参与者的发现，重点介绍了它们对细胞功能的特殊贡献。这些发现大大加深了我们对LD生物学的理解。

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New players on lipid droplets: Their regulations and functions

Lipid droplets (LDs) are highly conserved organelles found across a wide range of organisms, from prokaryotic to eukaryotes. LD proteins are a diverse group of proteins that are associated with LDs, regulating various aspects of LD function, such as storage, mobilization, and interactions with other organelles. Recent research in LD proteins has uncovered a broader range of physiological and pathological roles of LDs, extending beyond their traditional function in lipid metabolism. In this review, we summarize the mechanisms behind LD protein targeting and explore the discovery of new players on LDs, highlighting their specific contributions to cellular function. These discoveries significantly deepen our understanding of LD biology.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.