Vip3Aa和Vip3Ca结构域III的结构和功能作用：对膜穿孔和杀虫效果的影响

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2025-05-24 DOI:10.1002/ps.8922

Xiaoyue Hou, Chengjuan Mao, Wen Zhang, Lei Jiang, Mengying Li, Jixin Guo, Chenru Yang, Jinxuan Wang, Yaowei Fang, Xu Jiang, Jun Cai

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引用次数: 0

摘要

苏云金芽孢杆菌Cry蛋白在害虫防治中的广泛应用已导致部分鳞翅目害虫产生抗药性。由于不同的杀虫机制，缺乏与Cry毒素序列同源性的Vip3蛋白提供了一个有希望的替代方案。本研究探讨了Vip3蛋白结构域III和n端区域（P14-G22）之间的相互作用如何影响其激活效率和杀虫活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structural and functional roles of domain III in Vip3Aa and Vip3Ca: implications for membrane perforation and insecticidal efficacy

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Structural and functional roles of domain III in Vip3Aa and Vip3Ca: implications for membrane perforation and insecticidal efficacy

The widespread use of Bacillus thuringiensis Cry proteins in pest control has led to resistance in some lepidopteran pests. Vip3 proteins, lacking sequence homology with Cry toxins, offer a promising alternative due to distinct insecticidal mechanisms. This study investigates how modulating interactions between domain III and the N-terminal region (P14–G22) of Vip3 proteins influences their activation efficiency and insecticidal activity.

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.