Tyesha Coleman, Richard Bickel, John Noel, Kathleen R May
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Purpose of review: Hypereosinophilia is defined as an absolute eosinophil count greater than 1500 cells/mm3. This is a condition often observed in the pediatric population, with benign/self-resolving to life-threatening etiologies. Identifying the cause of hypereosinophilia can be challenging, given its broad associated differential diagnosis and diversity of presentations. This review provides an overview of eosinophil biology and explores causes of hypereosinophilia in children, emphasizing diagnostic and therapeutic challenges, while underscoring the importance of recognizing rare causes including primary hypereosinophilic syndrome (HES).
Recent findings: Classification of hypereosinophilic subtypes has evolved, as has understanding of etiologies with advances in modern diagnostic tools. Newer therapeutic options with low side-effect profiles have expanded treatment options in patients with HES. Despite recent improvements in medical management, HES remains a serious medical condition with considerable morbidity and potential mortality. Early identification and appropriate treatment can improve prognosis and reduce the burden of disease in children.
期刊介绍：
The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma.
We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.
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