Eva Grundmann, Ghazala Gohar, Simon Meier, Bertram Feil, Michael Gagesch
{"title":"老年类风湿关节炎患者接受巴比替尼治疗的社区获得性肺炎伴铜绿假单胞菌。","authors":"Eva Grundmann, Ghazala Gohar, Simon Meier, Bertram Feil, Michael Gagesch","doi":"10.4235/agmr.24.0191","DOIUrl":null,"url":null,"abstract":"<p><p>Community-acquired pneumonia (CAP) in older patients presents unique diagnostic challenges. Unlike typical presentations with fever and cough, older adults may experience atypical symptoms like falls, confusion, or chronic disease deterioration. Immunomodulatory treatments for autoimmune diseases further complicate infection risks. This is the first case of a severe Pseudomonas aeruginosa pneumonia in an 86-year-old rheumatoid arthritis patient on baricitinib and prednisone. Initially admitted after a fall, she showed no respiratory symptoms but had a chest x-ray revealing extensive infiltrative consolidation. Sputum analysis confirmed the pneumonia, which was successfully treated with antibiotics. Following the resolution of the infection, the immunomodulatory therapy could be safely reintroduced. The case underscores the critical need for comprehensive diagnostic evaluation in older adults on immunomodulatory therapy, emphasizing that subtle, non-respiratory symptoms can mask serious infections and require heightened clinical suspicion.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"414-417"},"PeriodicalIF":3.2000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489608/pdf/","citationCount":"0","resultStr":"{\"title\":\"Community-Acquired Pneumonia with Pseudomonas aeruginosa in a Geriatric Patient with Rheumatoid Arthritis under Baricitinib Treatment.\",\"authors\":\"Eva Grundmann, Ghazala Gohar, Simon Meier, Bertram Feil, Michael Gagesch\",\"doi\":\"10.4235/agmr.24.0191\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Community-acquired pneumonia (CAP) in older patients presents unique diagnostic challenges. Unlike typical presentations with fever and cough, older adults may experience atypical symptoms like falls, confusion, or chronic disease deterioration. Immunomodulatory treatments for autoimmune diseases further complicate infection risks. This is the first case of a severe Pseudomonas aeruginosa pneumonia in an 86-year-old rheumatoid arthritis patient on baricitinib and prednisone. Initially admitted after a fall, she showed no respiratory symptoms but had a chest x-ray revealing extensive infiltrative consolidation. Sputum analysis confirmed the pneumonia, which was successfully treated with antibiotics. Following the resolution of the infection, the immunomodulatory therapy could be safely reintroduced. The case underscores the critical need for comprehensive diagnostic evaluation in older adults on immunomodulatory therapy, emphasizing that subtle, non-respiratory symptoms can mask serious infections and require heightened clinical suspicion.</p>\",\"PeriodicalId\":44729,\"journal\":{\"name\":\"Annals of Geriatric Medicine and Research\",\"volume\":\" \",\"pages\":\"414-417\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489608/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Geriatric Medicine and Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4235/agmr.24.0191\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Geriatric Medicine and Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4235/agmr.24.0191","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Community-Acquired Pneumonia with Pseudomonas aeruginosa in a Geriatric Patient with Rheumatoid Arthritis under Baricitinib Treatment.
Community-acquired pneumonia (CAP) in older patients presents unique diagnostic challenges. Unlike typical presentations with fever and cough, older adults may experience atypical symptoms like falls, confusion, or chronic disease deterioration. Immunomodulatory treatments for autoimmune diseases further complicate infection risks. This is the first case of a severe Pseudomonas aeruginosa pneumonia in an 86-year-old rheumatoid arthritis patient on baricitinib and prednisone. Initially admitted after a fall, she showed no respiratory symptoms but had a chest x-ray revealing extensive infiltrative consolidation. Sputum analysis confirmed the pneumonia, which was successfully treated with antibiotics. Following the resolution of the infection, the immunomodulatory therapy could be safely reintroduced. The case underscores the critical need for comprehensive diagnostic evaluation in older adults on immunomodulatory therapy, emphasizing that subtle, non-respiratory symptoms can mask serious infections and require heightened clinical suspicion.