[zdhhc介导的蛋白棕榈酰化 在非小细胞肺癌发生和免疫逃逸中的研究进展及应用]。

Q4 Medicine

中国肺癌杂志 Pub Date : 2025-04-20 DOI:10.3779/j.issn.1009-3419.2025.102.15

Wangcheng Chen, Lili Pang, Yuemei Lan, Yanhong Shi, Bingbing Wen, Baihong Zhang

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引用次数: 0

摘要

非小细胞肺癌（NSCLC）是全球癌症相关死亡的主要原因，尽管免疫检查点抑制剂治疗取得了进展，但它仍然是一个重大的临床挑战，耐药性仍然是一个主要障碍。棕榈酰化是一种关键的翻译后修饰（PTM），主要由锌指dhhc型（ZDHHC）的棕榈酰转移酶催化，最近在NSCLC中显示出重要的意义。本文旨在阐明zdhhc介导的蛋白棕榈酰化在NSCLC进展和免疫逃逸中的机制和临床潜力。 。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

[Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation  in the Development and Immune Escape of Non-small Cell Lung Cancer].

Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (PTM) primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type (ZDHHC), has recently demonstrated important implications in NSCLC. This review aims to elucidate the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape. .

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来源期刊

中国肺癌杂志 Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

0.00%

发文量

5131

审稿时长

14 weeks

期刊介绍： Chinese Journal of Lung Cancer(CJLC, pISSN 1009-3419, eISSN 1999-6187), a monthly Open Access journal, is hosted by Chinese Anti-Cancer Association, Chinese Antituberculosis Association, Tianjin Medical University General Hospital. CJLC was indexed in DOAJ, EMBASE/SCOPUS, Chemical Abstract(CA), CSA-Biological Science, HINARI, EBSCO-CINAHL,CABI Abstract, Global Health, CNKI, etc. Editor-in-Chief: Professor Qinghua ZHOU.

[zdhhc介导的蛋白棕榈酰化 在非小细胞肺癌发生和免疫逃逸中的研究进展及应用]。

摘要

[zdhhc介导的蛋白棕榈酰化 在非小细胞肺癌发生和免疫逃逸中的研究进展及应用]。