Song Li, Kun Geng, Lin Yang, Yaling Zhang, Xiaoyang Tao, Jierui Cai, Linyang Li, Zemin Luo, Birendra Mahato, Yonglei Liu, Xiaoling Yin, Hiu Cai, Jishuai Zhao, Heyan Chen, Lixia Wang
{"title":"脑卒中急性期血清NLRP1炎性体与抑郁的相关性分析。","authors":"Song Li, Kun Geng, Lin Yang, Yaling Zhang, Xiaoyang Tao, Jierui Cai, Linyang Li, Zemin Luo, Birendra Mahato, Yonglei Liu, Xiaoling Yin, Hiu Cai, Jishuai Zhao, Heyan Chen, Lixia Wang","doi":"10.1159/000546439","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the correlation between serum NLRP1 inflammasome level and depressive state in acute stage of stroke.</p><p><strong>Methods: </strong>A total of 102 patients with acute stroke who were hospitalized for the first time in the Department of Neurology of the First Affiliated Hospital of Dali University from April 2023 to October 2023 were included, and 80 of them met the inclusion criteria. On the 7th day of admission, the patients were evaluated using the 24-item Hamilton Depression Scale (HAMD-24) and were divided into 31 patients in the acute stage of stroke depression group and 49 patients in the acute stage of stroke non-depression group. The general clinical data of patients were collected, the unified Stroke Scale score (NIHSS) and Pittsburgh Sleep Quality Index score (PSQI) were performed, and fasting serum was collected at 8 a.m. the next morning. NLRP1 inflammatory bodies (NLRP1, ASC, Caspase1) and inflammatory factors IL-1β, IL-18, IL-10, tumor necrosis factor (TNF)-α were detected.</p><p><strong>Results: </strong>(1) The incidence of depression in acute stage of stroke was 38.75%. (2) There were statistically significant differences in PSQI and NIHSS scores between the two groups (p < 0.05), and the scores were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (p < 0.05). (3) The expression levels of NLRP1, IL-18, and TNF-α in serum were significantly different between the two groups (p < 0.01), and the expression levels were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (p < 0.05). There were no significant differences in the expression levels of serum IL-1β, IL-10, Caspase-1 and ASC (p > 0.05). (4) Further analysis by stepwise fitting binary logistic regression showed that NIHSS score, NLRP1, and IL-18 level were independent risk factors for depression in acute stage of stroke (p < 0.05). (5) NIIHSS score, NLRP1, and IL-18 receiver operating characteristic curve area have certain predictive value for the occurrence and development of acute depression during stroke.</p><p><strong>Conclusion: </strong>The more severe the neurological impairment and sleep disorder, the higher the expression level of NLRP1 inflammasome in blood, and the more severe the depression in acute stage of stroke.</p>","PeriodicalId":19133,"journal":{"name":"Neuroimmunomodulation","volume":" ","pages":"150-160"},"PeriodicalIF":2.4000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation Analysis between Serum NLRP1 Inflammasome and Depression in Acute Stage of Stroke.\",\"authors\":\"Song Li, Kun Geng, Lin Yang, Yaling Zhang, Xiaoyang Tao, Jierui Cai, Linyang Li, Zemin Luo, Birendra Mahato, Yonglei Liu, Xiaoling Yin, Hiu Cai, Jishuai Zhao, Heyan Chen, Lixia Wang\",\"doi\":\"10.1159/000546439\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The aim of this study was to investigate the correlation between serum NLRP1 inflammasome level and depressive state in acute stage of stroke.</p><p><strong>Methods: </strong>A total of 102 patients with acute stroke who were hospitalized for the first time in the Department of Neurology of the First Affiliated Hospital of Dali University from April 2023 to October 2023 were included, and 80 of them met the inclusion criteria. On the 7th day of admission, the patients were evaluated using the 24-item Hamilton Depression Scale (HAMD-24) and were divided into 31 patients in the acute stage of stroke depression group and 49 patients in the acute stage of stroke non-depression group. The general clinical data of patients were collected, the unified Stroke Scale score (NIHSS) and Pittsburgh Sleep Quality Index score (PSQI) were performed, and fasting serum was collected at 8 a.m. the next morning. NLRP1 inflammatory bodies (NLRP1, ASC, Caspase1) and inflammatory factors IL-1β, IL-18, IL-10, tumor necrosis factor (TNF)-α were detected.</p><p><strong>Results: </strong>(1) The incidence of depression in acute stage of stroke was 38.75%. (2) There were statistically significant differences in PSQI and NIHSS scores between the two groups (p < 0.05), and the scores were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (p < 0.05). (3) The expression levels of NLRP1, IL-18, and TNF-α in serum were significantly different between the two groups (p < 0.01), and the expression levels were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (p < 0.05). There were no significant differences in the expression levels of serum IL-1β, IL-10, Caspase-1 and ASC (p > 0.05). (4) Further analysis by stepwise fitting binary logistic regression showed that NIHSS score, NLRP1, and IL-18 level were independent risk factors for depression in acute stage of stroke (p < 0.05). (5) NIIHSS score, NLRP1, and IL-18 receiver operating characteristic curve area have certain predictive value for the occurrence and development of acute depression during stroke.</p><p><strong>Conclusion: </strong>The more severe the neurological impairment and sleep disorder, the higher the expression level of NLRP1 inflammasome in blood, and the more severe the depression in acute stage of stroke.</p>\",\"PeriodicalId\":19133,\"journal\":{\"name\":\"Neuroimmunomodulation\",\"volume\":\" \",\"pages\":\"150-160\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroimmunomodulation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000546439\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimmunomodulation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546439","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Correlation Analysis between Serum NLRP1 Inflammasome and Depression in Acute Stage of Stroke.
Introduction: The aim of this study was to investigate the correlation between serum NLRP1 inflammasome level and depressive state in acute stage of stroke.
Methods: A total of 102 patients with acute stroke who were hospitalized for the first time in the Department of Neurology of the First Affiliated Hospital of Dali University from April 2023 to October 2023 were included, and 80 of them met the inclusion criteria. On the 7th day of admission, the patients were evaluated using the 24-item Hamilton Depression Scale (HAMD-24) and were divided into 31 patients in the acute stage of stroke depression group and 49 patients in the acute stage of stroke non-depression group. The general clinical data of patients were collected, the unified Stroke Scale score (NIHSS) and Pittsburgh Sleep Quality Index score (PSQI) were performed, and fasting serum was collected at 8 a.m. the next morning. NLRP1 inflammatory bodies (NLRP1, ASC, Caspase1) and inflammatory factors IL-1β, IL-18, IL-10, tumor necrosis factor (TNF)-α were detected.
Results: (1) The incidence of depression in acute stage of stroke was 38.75%. (2) There were statistically significant differences in PSQI and NIHSS scores between the two groups (p < 0.05), and the scores were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (p < 0.05). (3) The expression levels of NLRP1, IL-18, and TNF-α in serum were significantly different between the two groups (p < 0.01), and the expression levels were correlated with the degree of depression, and were positively correlated with HAMD-24 scores (p < 0.05). There were no significant differences in the expression levels of serum IL-1β, IL-10, Caspase-1 and ASC (p > 0.05). (4) Further analysis by stepwise fitting binary logistic regression showed that NIHSS score, NLRP1, and IL-18 level were independent risk factors for depression in acute stage of stroke (p < 0.05). (5) NIIHSS score, NLRP1, and IL-18 receiver operating characteristic curve area have certain predictive value for the occurrence and development of acute depression during stroke.
Conclusion: The more severe the neurological impairment and sleep disorder, the higher the expression level of NLRP1 inflammasome in blood, and the more severe the depression in acute stage of stroke.
期刊介绍：
The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.
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