Alessandro Sclafani, Jairo H Migueles, Marcos Olvera-Rojas, Patricio Solis-Urra, Beatriz Fernandez-Gamez, Andrea Coca-Pulido, Darío Bellón, Javier Fernández-Ortega, Javier Sanchez-Martinez, Lucía Sánchez-Aranda, Ángel Toval, Isabel Martín-Fuentes, Esmée A Bakker, Juan D Gispert, Eva M Triviño-Ibañez, Teresa Liu-Ambrose, Kirk I Erickson, Manuel Gomez-Rio, Francisco B Ortega, Irene Esteban-Cornejo
{"title":"在认知正常的老年人中，24个 h-运动行为与大脑和海马淀粉样蛋白水平和执行功能的关联：AGUEDA试验的组成数据分析。","authors":"Alessandro Sclafani, Jairo H Migueles, Marcos Olvera-Rojas, Patricio Solis-Urra, Beatriz Fernandez-Gamez, Andrea Coca-Pulido, Darío Bellón, Javier Fernández-Ortega, Javier Sanchez-Martinez, Lucía Sánchez-Aranda, Ángel Toval, Isabel Martín-Fuentes, Esmée A Bakker, Juan D Gispert, Eva M Triviño-Ibañez, Teresa Liu-Ambrose, Kirk I Erickson, Manuel Gomez-Rio, Francisco B Ortega, Irene Esteban-Cornejo","doi":"10.1016/j.jsams.2025.04.011","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the associations between movement behaviors (physical activity, sedentary behavior, and sleep duration), global and hippocampal amyloid beta levels, and executive function in cognitively normal older adults.</p><p><strong>Design: </strong>Cross-sectional analysis using data from the Active Gains in brain Using Exercise During Aging study, including 86 participants (mean age 71.51 years, 57% female).</p><p><strong>Methods: </strong>Movement behaviors were assessed using a wrist-worn accelerometer over a 9-day. Amyloid beta levels were quantified via positron emission tomography, and executive function was assessed using validated cognitive tests (e.g., Trail Making Test, Digit Symbol Substitution Test, Spatial Working Memory test, and Dimensional Change Card Sort test). Compositional data analysis and multiple linear regression models were used to examine associations, adjusting for age, sex, education, and APOEε4 genotype status.</p><p><strong>Results: </strong>No significant associations emerged between any movement behaviors and total cerebral amyloid beta levels or executive function (all p > 0.05). However, higher moderate-to-vigorous physical activity was significantly associated with lower hippocampal amyloid levels in males (β = -0.039, p = 0.010), but not in females (β = 0.004, p = 0.741) (Moderate-to-vigorous physical activity × sex interaction p = 0.017).</p><p><strong>Conclusions: </strong>Movement behaviors were not associated with global amyloid levels or executive function. However, higher moderate-to-vigorous physical activity may be protective against hippocampal amyloid levels in older males. Further research is needed to confirm these findings and explore potential sex differences. These results underscore the importance of moderate-to-vigorous physical activity in brain health and suggest avenues for future research on the role of movement behaviors in amyloid burden.</p>","PeriodicalId":16992,"journal":{"name":"Journal of science and medicine in sport","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial.\",\"authors\":\"Alessandro Sclafani, Jairo H Migueles, Marcos Olvera-Rojas, Patricio Solis-Urra, Beatriz Fernandez-Gamez, Andrea Coca-Pulido, Darío Bellón, Javier Fernández-Ortega, Javier Sanchez-Martinez, Lucía Sánchez-Aranda, Ángel Toval, Isabel Martín-Fuentes, Esmée A Bakker, Juan D Gispert, Eva M Triviño-Ibañez, Teresa Liu-Ambrose, Kirk I Erickson, Manuel Gomez-Rio, Francisco B Ortega, Irene Esteban-Cornejo\",\"doi\":\"10.1016/j.jsams.2025.04.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study investigated the associations between movement behaviors (physical activity, sedentary behavior, and sleep duration), global and hippocampal amyloid beta levels, and executive function in cognitively normal older adults.</p><p><strong>Design: </strong>Cross-sectional analysis using data from the Active Gains in brain Using Exercise During Aging study, including 86 participants (mean age 71.51 years, 57% female).</p><p><strong>Methods: </strong>Movement behaviors were assessed using a wrist-worn accelerometer over a 9-day. Amyloid beta levels were quantified via positron emission tomography, and executive function was assessed using validated cognitive tests (e.g., Trail Making Test, Digit Symbol Substitution Test, Spatial Working Memory test, and Dimensional Change Card Sort test). Compositional data analysis and multiple linear regression models were used to examine associations, adjusting for age, sex, education, and APOEε4 genotype status.</p><p><strong>Results: </strong>No significant associations emerged between any movement behaviors and total cerebral amyloid beta levels or executive function (all p > 0.05). However, higher moderate-to-vigorous physical activity was significantly associated with lower hippocampal amyloid levels in males (β = -0.039, p = 0.010), but not in females (β = 0.004, p = 0.741) (Moderate-to-vigorous physical activity × sex interaction p = 0.017).</p><p><strong>Conclusions: </strong>Movement behaviors were not associated with global amyloid levels or executive function. However, higher moderate-to-vigorous physical activity may be protective against hippocampal amyloid levels in older males. Further research is needed to confirm these findings and explore potential sex differences. These results underscore the importance of moderate-to-vigorous physical activity in brain health and suggest avenues for future research on the role of movement behaviors in amyloid burden.</p>\",\"PeriodicalId\":16992,\"journal\":{\"name\":\"Journal of science and medicine in sport\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of science and medicine in sport\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jsams.2025.04.011\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SPORT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of science and medicine in sport","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jsams.2025.04.011","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial.
Objectives: This study investigated the associations between movement behaviors (physical activity, sedentary behavior, and sleep duration), global and hippocampal amyloid beta levels, and executive function in cognitively normal older adults.
Design: Cross-sectional analysis using data from the Active Gains in brain Using Exercise During Aging study, including 86 participants (mean age 71.51 years, 57% female).
Methods: Movement behaviors were assessed using a wrist-worn accelerometer over a 9-day. Amyloid beta levels were quantified via positron emission tomography, and executive function was assessed using validated cognitive tests (e.g., Trail Making Test, Digit Symbol Substitution Test, Spatial Working Memory test, and Dimensional Change Card Sort test). Compositional data analysis and multiple linear regression models were used to examine associations, adjusting for age, sex, education, and APOEε4 genotype status.
Results: No significant associations emerged between any movement behaviors and total cerebral amyloid beta levels or executive function (all p > 0.05). However, higher moderate-to-vigorous physical activity was significantly associated with lower hippocampal amyloid levels in males (β = -0.039, p = 0.010), but not in females (β = 0.004, p = 0.741) (Moderate-to-vigorous physical activity × sex interaction p = 0.017).
Conclusions: Movement behaviors were not associated with global amyloid levels or executive function. However, higher moderate-to-vigorous physical activity may be protective against hippocampal amyloid levels in older males. Further research is needed to confirm these findings and explore potential sex differences. These results underscore the importance of moderate-to-vigorous physical activity in brain health and suggest avenues for future research on the role of movement behaviors in amyloid burden.
期刊介绍：
The Journal of Science and Medicine in Sport is the official journal of Sports Medicine Australia (SMA) and is an an international refereed research publication covering all aspects of sport science and medicine.
The Journal considers for publication Original research and Review papers in the sub-disciplines relating generally to the broad sports medicine and sports science fields: sports medicine, sports injury (including injury epidemiology and injury prevention), physiotherapy, podiatry, physical activity and health, sports science, biomechanics, exercise physiology, motor control and learning, sport and exercise psychology, sports nutrition, public health (as relevant to sport and exercise), and rehabilitation and injury management. Manuscripts with an interdisciplinary perspective with specific applications to sport and exercise and its interaction with health will also be considered.
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