Joanne Byrne, Colette Marie Gaillard, Lili Gu, Alejandro Garcia-Leon, Orlaith Casey, Grace Kenny, Gurvin Saini, Dana Alalwan, Tessa O'Gorman, Siobhan O'Regan, Peter Doran, Eoin R Feeney, Jane A O'Halloran, Mary Horgan, Aoife G Cotter, Eoghan de Barra, Corinna Sadlier, Alan Landay, Virginie Gautier, Patrick W G Mallon
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引用次数: 0
摘要
较高的循环SARS-CoV-2 IgG滴度与SARS-CoV-2体外病毒中和相关，但在现实环境中，这在多大程度上转化为临床保护尚不清楚。在一项前瞻性队列研究中，我们招募了44名SARS-CoV-2阴性、确诊的密切接触者。在暴露时测量受体结合域（RBD）和全刺突IgG和SARS-CoV-2记忆b细胞频率，并在14天内对参与者进行连续的意外感染测试。那些发生SARS-CoV-2感染的人RBD滴度显著降低，但记忆b细胞频率没有显著降低。RBD IgG滴度>6321 BAU/ml与SARS-CoV-2感染风险降低相关（HR 0.32, 95% CI 0.13-0.81），而RBD IgG滴度>456 BAU/ml与中度或重度COVID-19风险降低相关（HR 0.15, 95% CI 0.03-0.81），确定该阈值与保护相关。
Specific thresholds of circulating antibody titers predict against infection and reduced disease severity in SARS-CoV-2 close contacts.
Higher circulating SARS-CoV-2 IgG titers correlate with SARS-CoV-2 ex vivo viral neutralization, but how well this translates to clinical protection in the real-world setting is unclear. In a prospective cohort study, we enrolled 44 SARS-CoV-2 negative, confirmed SARS-CoV-2 close contacts. Receptor-binding domain (RBD) and full-spike IgG and SARS-CoV-2 memory B-cell frequencies were measured at exposure, and participants were serially tested for incident infection over 14 days. Those who developed SARS-CoV-2 infection had significantly lower RBD titers, but not memory B-cell frequencies. An RBD IgG titer >6321 BAU/ml was associated with a reduced SARS-CoV-2 acquisition risk (HR 0.32, 95% CI 0.13-0.81), while an RBD IgG titer >456 BAU/ml was associated with a reduced moderate or severe COVID-19 risk (HR 0.15, 95% CI 0.03-0.81), identifying this threshold as a correlate of protection.
期刊介绍：
The JI publishes novel, peer-reviewed findings in all areas of experimental immunology, including innate and adaptive immunity, inflammation, host defense, clinical immunology, autoimmunity and more. Special sections include Cutting Edge articles, Brief Reviews and Pillars of Immunology. The JI is published by The American Association of Immunologists (AAI)
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