The Incidence of Sport-Related Anterior Cruciate Ligament Injuries: An Overview of Systematic Reviews Including 51 Meta-Analyses.

Background/Objectives: The number of systematic reviews evaluating the incidence of anterior cruciate ligament (ACL) injuries in sports is increasing. To synthesize pooled incidence and prevalence rates of sport-related ACL injuries based on published systematic reviews with meta-analyses. Methods: An overview of systematic reviews with meta-analysis was conducted. The CINAHL, Embase, PubMed, and SPORTDiscus databases were searched from inception to 17 October 2023. AMSTAR 2 was used to assess the methodological quality of reviews. The degree of overlap between reviews was calculated when possible. Results: Seven systematic reviews including 51 meta-analyses of interest were included. The prevalence of ACL injuries was not meta-analyzed. Meta-analyses mainly showed that ACL injuries may have a high incidence in American football, basketball, European football/soccer, and volleyball, among other sports. In addition, ACL injuries may have a higher incidence in females than males in some sports. For example, the pooled incidence rates of ACL injuries in basketball ranged from 0.091 (95%CI, 0.074-0.111) to 0.110 (95%CI, 0.094-0.128) among female athletes, whereas this incidence ranged from 0.024 (95%CI, 0.016-0.034) to 0.027 (95%CI, 0.019-0.035) among male athletes. Conclusions: Sport-related ACL injuries may have a high incidence in sports such as American football, basketball, European football/soccer, or volleyball and show differences between sexes. Therefore, a sex-specific prevention of these injuries may be needed.