Klippel-Trenaunay综合征和CLOVES综合征的门静脉扩张。

IF 1.5 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Asma Maqsood, Jaime Alonso Sanchez, Gary Peiser, Aisling Carroll-Downey, Maria F Dien Equivel, Joao Amaral, Laura Willis, Manuel Carcao, Alessandro Gasparetto
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引用次数: 0

摘要

背景:Klippel-Trenaunay综合征(KTS)和先天性脂肪瘤过度生长、血管异常、表皮痣和骨骼异常(CLOVES)综合征是罕见的与过度生长和血管异常相关的疾病,更常累及下肢。虽然不常见,但这些综合征可能与门静脉(PV)异常有关,包括PV血栓形成和PV高血压。在这项研究中,我们描述了5例KTS或CLOVES患者的PV扩张的其他发现。方法:一项20年的回顾性研究对下肢血管异常和过度生长患者的PV表现进行了评估。两名放射科医生回顾了影像学检查(US, CT和MRI)并记录了血管改变的类型和位置。结果:35例患者(女性25例,KTS 24例,CLOVES 7例,其他4例,中位年龄8.5岁)有腹部显像,5例患者有PV扩张,1例有PV血栓形成。所有患者均伴有腹部血管异常。结论:系统评估KTS和CLOVES患者的腹腔骨盆区域可以识别血管异常,包括PV扩张,这可能表明血栓前状态。早期发现和监测这些发现对预防门静脉高压和血栓形成等并发症具有临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Portal vein dilation in Klippel-Trenaunay and CLOVES syndromes.

Background: Klippel-Trenaunay Syndrome (KTS) and congenital lipomatous overgrowth, vascular anomalies, epidermal nevi and skeletal abnormalities (CLOVES) syndrome are rare conditions associated with overgrowth and vascular anomalies more frequently involving the lower extremities. Although uncommon, these syndromes can be associated with portal vein (PV) abnormalities, including PV thrombosis, and PV hypertension. In this study, we describe additional findings of PV dilation in five patients with KTS or CLOVES.

Methods: A single institution 20 year retrospective review was performed to evaluate PV findings in patients with vascular anomalies and overgrowth of the lower extremities. Two radiologists reviewed the imaging examinations (US, CT and MRI) and recorded type and location of vascular alterations.

Results: Of 35 patients (25 females, 24 KTS, 7 CLOVES and 4 other, median age: 8.5 years) with available abdominal imaging, 5 patients had PV dilation and one PV thrombosis. All patients presented additional abdominal vascular anomalies in association.

Conclusions: Systematic evaluation of the abdominopelvic region in patients with KTS and CLOVES can identify vascular anomalies, including PV dilation, which may indicate a prethrombotic state. Early detection and monitoring of these findings could have clinical implications for preventing complications such as portal hypertension and thrombosis.

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来源期刊
International Angiology
International Angiology 医学-外周血管病
CiteScore
2.80
自引率
28.60%
发文量
89
审稿时长
6-12 weeks
期刊介绍: International Angiology publishes scientific papers on angiology. Manuscripts may be submitted in the form of editorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work. Duties and responsibilities of all the subjects involved in the editorial process are summarized at Publication ethics. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors (ICMJE).
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