Christian H Steenkjær, Mia B Heintzelmann, Izabella Obál, Grethe Andersen, Jakob U Blicher
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The aim of this study was to provide a Danish translation of the CNS-LS inspired by international guidelines on cross-cultural translation and adaptation of self-report measurements.</p><p><strong>Methods: </strong>Through a six-step process, the CNS-LS was translated and back-translated by four certified translators, followed by an expert committee examination. The translation was then field-tested by interviewing patients with ALS and MS after they had completed the CNS-LS. If at least 20% of participants found an item \"unclear\", it would be reevaluated.</p><p><strong>Results: </strong>Twelve patients with ALS patients and 30 patients with MS were tested and interviewed. None of the questionnaire items exceeded the 20% threshold for lack of clarity.</p><p><strong>Conclusion: </strong>We present a Danish translation of the CNS-LS to facilitate better diagnosis and quantification of PBA symptoms in Danish patients with ALS or MS.</p><p><strong>Funding: </strong>This study received funding from the PhD fellowship grant of Neuroscience Academy Denmark.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 5","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An adapted Danish translation of the Center for Neurologic Study Lability scale.\",\"authors\":\"Christian H Steenkjær, Mia B Heintzelmann, Izabella Obál, Grethe Andersen, Jakob U Blicher\",\"doi\":\"10.61409/A07240497\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Pathological crying and/or laughing (pseudobulbar affect (PBA)) are socially debilitating symptoms seen in many neurological diseases, such as stroke, multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). One method for measuring the degree of PBA is the Center for Neurologic Study-Lability Scale (CNS-LS), a seven-item questionnaire validated for quantifying symptoms and supporting PBA diagnoses in ALS and MS. The aim of this study was to provide a Danish translation of the CNS-LS inspired by international guidelines on cross-cultural translation and adaptation of self-report measurements.</p><p><strong>Methods: </strong>Through a six-step process, the CNS-LS was translated and back-translated by four certified translators, followed by an expert committee examination. The translation was then field-tested by interviewing patients with ALS and MS after they had completed the CNS-LS. If at least 20% of participants found an item \\\"unclear\\\", it would be reevaluated.</p><p><strong>Results: </strong>Twelve patients with ALS patients and 30 patients with MS were tested and interviewed. 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An adapted Danish translation of the Center for Neurologic Study Lability scale.
Introduction: Pathological crying and/or laughing (pseudobulbar affect (PBA)) are socially debilitating symptoms seen in many neurological diseases, such as stroke, multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). One method for measuring the degree of PBA is the Center for Neurologic Study-Lability Scale (CNS-LS), a seven-item questionnaire validated for quantifying symptoms and supporting PBA diagnoses in ALS and MS. The aim of this study was to provide a Danish translation of the CNS-LS inspired by international guidelines on cross-cultural translation and adaptation of self-report measurements.
Methods: Through a six-step process, the CNS-LS was translated and back-translated by four certified translators, followed by an expert committee examination. The translation was then field-tested by interviewing patients with ALS and MS after they had completed the CNS-LS. If at least 20% of participants found an item "unclear", it would be reevaluated.
Results: Twelve patients with ALS patients and 30 patients with MS were tested and interviewed. None of the questionnaire items exceeded the 20% threshold for lack of clarity.
Conclusion: We present a Danish translation of the CNS-LS to facilitate better diagnosis and quantification of PBA symptoms in Danish patients with ALS or MS.
Funding: This study received funding from the PhD fellowship grant of Neuroscience Academy Denmark.
期刊介绍:
The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content.
DMJ will publish the following articles:
• Original articles
• Protocol articles from large randomized clinical trials
• Systematic reviews and meta-analyses
• PhD theses from Danish faculties of health sciences
• DMSc theses from Danish faculties of health sciences.