An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles

Oxytocin is a conserved neuropeptide that regulates social and reproductive behaviors in diverse species. Genetic variation in Oxtr, the gene encoding the oxytocin receptor (OXTR), is associated with variation in social attachment behaviors in rodents and humans; however, it is unclear how genetic variation in Oxtr shapes the function of specific neural systems during social contexts. Here we address this question using the socially monogamous prairie vole (Microtus ochrogaster), a species that expresses an array of OXTR-dependent social behaviors and possesses Oxtr gene polymorphisms that predict individual variation in brain region-specific OXTR expression. We test the neural and behavioral effects of an Oxtr gene polymorphism that has previously been associated with brain region-specific OXTR expression and social attachment behaviors in male prairie voles. Our results suggest that, during brief mating encounters, Oxtr genotype is not associated with differences in mating behavior or in expression levels of the activity-dependent immediate early gene product FOS within brain regions, but it is associated with differences in correlated FOS expression patterns across brain regions.