zr - mof衍生的氧化锆纳米酶及其水凝胶复合膜解毒有机磷。

IF 4.7 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2025-05-22 DOI:10.1021/acs.inorgchem.5c01454

Hong-Bin Luo,Zhi-Xing Han,Kai-Xin Zhao,Xin-Ru Wu,Wei-Jie Cai,Yangyang Liu,Xiao-Ming Ren

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引用次数: 0

摘要

有机磷神经毒剂是最危险的化学战剂之一，对人类健康构成严重威胁。开发高效的脱毒催化剂和复合材料仍然是一个重大挑战。在这项研究中，我们提出了从锆基金属有机框架（Zr-MOF）衍生的氧化锆（ZrOx）纳米酶的第一个例子，它对神经毒剂模拟物二甲基-4-硝基苯基磷酸（DMNP）的水解表现出出色的催化活性。此外，将ZrOx掺入以1,4-重氮杂环[2.2.2]辛烷（dabco）为基底的聚乙烯醇（PVA）基质中，形成水凝胶复合膜，命名为ZrOx@PD。值得注意的是，ZrOx@PD在环境条件下对DMNP的固相水解表现出卓越的催化效率，优于许多先前报道的催化材料，并突出了其作为神经毒剂保护材料的潜力。

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Zr-MOF-Derived Zirconium Oxide Nanozyme and Its Hydrogel Composite Membrane for Organophosphate Detoxification.

Organophosphorus nerve agents are among the most hazardous chemical warfare agents, posing serious risks to human health. Developing efficient catalysts and composite materials for their detoxification remains a significant challenge. In this study, we present the first example of zirconium oxide (ZrOx) nanozyme derived from a zirconium-based metal-organic framework (Zr-MOF), which exhibits outstanding catalytic activity for the hydrolysis of a nerve agent simulant, dimethyl-4-nitrophenyl phosphate (DMNP). Moreover, ZrOx was incorporated into a poly(vinyl alcohol) (PVA) matrix with 1,4-diazabicyclo[2.2.2]octane (dabco) as a base, forming a hydrogel composite membrane, named ZrOx@PD. Notably, ZrOx@PD demonstrates superior catalytic efficiency for the solid-phase hydrolysis of DMNP under ambient conditions, outperforming many previously reported catalytic materials and highlighting its potential as a protective material against nerve agents.

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.