生殖细胞和其他肿瘤个体在性发育方面存在差异。

IF 232.4 1区医学 Q1 ONCOLOGY

CA: A Cancer Journal for Clinicians Pub Date : 2025-05-23 DOI:10.3322/caac.70015

Selma Feldman Witchel,Miguel Reyes-Múgica

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引用次数: 0

摘要

大约每3500到5100个活产婴儿中就有1个患有非典型外生殖器发育，称为性发育差异（DSD）。2005年，一次专家共识会议彻底审查了DSD患者保健的各个方面。会议提出了一个分类系统，以帮助提供个性化的评估和管理。某些类型的DSD与生殖细胞肿瘤有关，生殖细胞肿瘤由源自生殖细胞的异质肿瘤组成。这些肿瘤常见于婴儿、儿童、青少年和年轻人。在此，概述了dsd和生殖细胞肿瘤的风险。

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Germ cell and other tumors in individuals with differences in sex development.

Approximately one in 3500 to one in 5100 live-born infants have atypical external genital development, known as differences in sex development (DSD). In 2005, an expert consensus conference thoroughly reviewed aspects of health care for individuals with DSD. The conference proposed a classification system to help provide individualized evaluations and management. Some types of DSD are associated with germ cell tumors, which comprise a heterogeneous group of neoplasms derived from germline cells. These neoplasms commonly occur in infants, children, adolescents, and young adults. Herein, an overview of DSDs and risks for germ cell tumors is provided.

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来源期刊

CA: A Cancer Journal for Clinicians 医学-肿瘤学

CiteScore

873.20

自引率

0.10%

发文量

审稿时长

1 months

期刊介绍： CA: A Cancer Journal for Clinicians" has been published by the American Cancer Society since 1950, making it one of the oldest peer-reviewed journals in oncology. It maintains the highest impact factor among all ISI-ranked journals. The journal effectively reaches a broad and diverse audience of health professionals, offering a unique platform to disseminate information on cancer prevention, early detection, various treatment modalities, palliative care, advocacy matters, quality-of-life topics, and more. As the premier journal of the American Cancer Society, it publishes mission-driven content that significantly influences patient care.