Emma Packer,Héloïse Debelle,Harry G B Bailey,Rana Zia Ur Rehman,Alison J Yarnall,Lynn Rochester,Lisa Alcock,Silvia Del Din
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引用次数: 0
摘要
为了改善运动功能和症状,帕金森病患者通常服用多巴胺能药物。在PwP中,可穿戴技术(WT)可以提供对药物效果的客观洞察。本综述旨在识别和探索使用WT量化药物对PwP患者运动功能和症状影响的文献(PROSPERO 2022 CRD42022310018)。在2000年1月至2024年10月期间检索了9个数据库。Downs和Black质量评价评价了学习质量。遵循PRISMA准则。在纳入的79项研究中,将50种不同的WTs放置在身体的20个位置,并对13种不同的运动功能/症状进行药物效果监测。方案之间存在很大的异质性,但许多研究是在受控环境中进行的,探索短期药物效应(ON vs OFF)。用药效果各不相同,改善了某些变量,而对其他变量没有影响。未来的研究应该确定金标准方案,以探索在现实环境中长期的药物效果。注册与协议PROSPERO 2022 CRD42022310018。
Systematic review of wearables assessing medication effect on motor function and symptoms in Parkinson's disease.
To improve motor function and symptoms, people with Parkinson's (PwP) typically take dopaminergic medication. In PwP, wearable technology (WT) can provide objective insights into medication effect. This review aims to identify and explore literature which uses WT to quantify the effect of medication on motor function and symptoms in PwP (PROSPERO 2022 CRD42022310018). Nine databases were searched between January 2000-October 2024. Downs and Black quality appraisal assessed study quality. PRISMA guidelines were followed. Amongst the seventy-nine included studies, 50 different WTs were placed across 20 locations on the body, and medication effect was monitored on 13 different motor functions/symptoms. There was great heterogeneity amongst protocols, but many studies were performed in controlled environments, exploring short-term medication effects (ON vs OFF). Medication effect varied, improving certain variables, and having no effect on others. Future research should identify gold-standard protocols to explore medication effect in real-world settings, over prolonged periods.Registration and Protocol PROSPERO 2022 CRD42022310018.
期刊介绍:
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.