{"title":"通过相分离激活受体影响心脏保存质量。","authors":"","doi":"10.1038/s44161-025-00668-4","DOIUrl":null,"url":null,"abstract":"A phenomenon of mineralocorticoid receptor phase separation exacerbates injury to mouse and human donor hearts during cold storage. Pharmacological inhibition of the mineralocorticoid receptor reduces the phase separation potential and improves preservation quality.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 6","pages":"659-660"},"PeriodicalIF":10.8000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Receptor activation via phase separation affects cardiac preservation quality\",\"authors\":\"\",\"doi\":\"10.1038/s44161-025-00668-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A phenomenon of mineralocorticoid receptor phase separation exacerbates injury to mouse and human donor hearts during cold storage. Pharmacological inhibition of the mineralocorticoid receptor reduces the phase separation potential and improves preservation quality.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 6\",\"pages\":\"659-660\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00668-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00668-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Receptor activation via phase separation affects cardiac preservation quality
A phenomenon of mineralocorticoid receptor phase separation exacerbates injury to mouse and human donor hearts during cold storage. Pharmacological inhibition of the mineralocorticoid receptor reduces the phase separation potential and improves preservation quality.
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