肝脂肪变性与年龄相关性黄斑变性之间的关系：一项横断面研究。

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-05-12 DOI:10.1097/IAE.0000000000004526

Patrick Wang, Zoe Hu, Maera Haider, Wilma Hopman, Evan Sharma, Sanjay Sharma

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引用次数: 0

摘要

目的：本研究的主要目的是评估年龄相关性黄斑变性（AMD）患者肝脂肪变性的相关性。方法：招募无继发性慢性肝病的AMD患者，以及年龄和性别匹配的对照组。通过超声成像确定肝脂肪变性，并通过标准化调查收集代谢危险因素。结果：共纳入98例患者（49例，49例对照）。AMD组肝脏脂肪变性发生率为51.0%，对照组为30.6%，差异有统计学意义（χ2(1) = 4.224, p = 0.040）。在多变量模型中，血脂异常和糖尿病是最强的预测因子，脂肪变性的相关性减弱，但仍然显著（OR 2.36, 95% CI 1.03-5.40, p = 0.049）。结论：本研究表明，在控制代谢危险因素后，AMD与肝脂肪变性患病率之间存在关联。

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The Association Between Hepatic Steatosis and Age-Related Macular Degeneration: A Cross-Sectional Study.

Purpose: The primary aim of this study is to estimate the association of hepatic steatosis in patients diagnosed with Age-Related Macular Degeneration (AMD).

Methods: Patients with AMD and without secondary causes of chronic liver disease, alongside age- and sex-matched controls were recruited. Hepatic steatosis was determined via ultrasound imaging, and metabolic risk factors were collected using standardized surveys.

Results: A total of 98 patients were recruited (49 cases, 49 controls). Hepatic steatosis was observed in 51.0% of the AMD group compared to 30.6% in controls, a statistically significant difference (χ2(1) = 4.224, p = 0.040). In multivariable models, dyslipidemia and diabetes were the strongest predictors, with association of steatosis attenuated but still significant (OR 2.36, 95% CI 1.03-5.40, p = 0.049).

Conclusion: This study suggests an association between AMD and the prevalence of hepatic steatosis, after controlling for metabolic risk factors.

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.