Investigating the effect aerials part of Stachys Lavandulifolia ointment on 2nd degree burns compared to silver sulfadiazine on male rat.

Objective: Skin burns can occur due to exposure to heat, chemicals, electricity, or sunlight, and can cause significant damage to the skin. Burns are classified based on their severity. Research has indicated that herbal extracts may help treat burns. This study aimed to assess the effectiveness of Stachys Lavandulifolia extract ointment in healing burn wounds in rats.

Methods: In this study, the efficacy of Stachys Lavandulifolia ointment was evaluated in treating second-degree burns by comparing it with silver sulfadiazine ointment. The study involved preparing Stachys Lavandulifolia extract in 2% and 4% concentrations. Thirty Wistar rats were divided into six groups, including a negative control group, a positive control group, and groups treated with silver sulfadiazine ointment, Stachys Lavandulifolia extract at 2% and 4% concentrations, and Eucerin ointment.

Results: The study found that applying 2% Stachys Lavandulifolia ointment is effective in treating second-degree burns. Biochemical analysis revealed significant differences in tissue FRAPS levels between the normal control group and the groups treated with 2% Stachys Lavandulifolia, 4% Stachys Lavandulifolia, and 1% silver sulfadiazine ointment. Statistical analysis indicated that on day 21, the burn area in the 2% and 4% Stachys Lavandulifolia ointment groups was significantly smaller than in the positive control and Eucerin groups.

Conclusion: The Stachys Lavandulifolia ointment, with its antioxidant ingredients, can potentially prevent oxidative damage, lower inflammatory factors, and speed up the healing process for burns.