n6 -甲基腺苷修饰和ncrna在风湿病中的串扰:治疗和诊断意义

IF 4.8 3区 医学 Q2 CELL BIOLOGY
Jianting Wen, Jian Liu, Lei Wan, Yue Sun, Fanfan Wang
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引用次数: 0

摘要

背景:在真核细胞中,n6 -甲基腺苷(m6A)是最常见的RNA甲基化修饰,通过调节非编码RNA (ncRNA)的表达和活性,在调节多种生物过程中发挥着重要作用。m6A修饰在风湿病发生中的作用是至关重要的,但研究仍不充分。方法:类风湿关节炎(RA)、骨关节炎(OA)、强直性脊柱炎(AS)、系统性红斑狼疮(SLE)等风湿性疾病是一种以疼痛和炎症为特征的自身免疫性疾病。最近的研究结果强调了m6A修饰和非编码rna在风湿性疾病的生物学过程中的重要性。结果:本文综述了m6A修饰的基本概念和相关的研究方法。随后,系统整合m6A调控因子和m6A修饰相关ncrna对风湿性疾病影响的现代知识,并纳入中医干预的观点。结论:本综述对风湿性疾病中m6A相关ncrna进行了全面概述,提出了针对m6A修饰途径的新治疗途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crosstalk between N6-methyladenosine modification and ncRNAs in rheumatic diseases: therapeutic and diagnostic implications.

Background: In eukaryotic cells, N6-methyladenosine (m6A) is the most prevalent RNA methylation modification and plays a fundamental role in regulating diverse biological processes through the modulation of non-coding RNA (ncRNA) expression and activity. The role of m6A modification in developing rheumatic diseases is crucial but remains inadequately studied.

Methods: Characterized by pain and inflammation, rheumatic diseases like rheumatoid arthritis (RA), osteoarthritis (OA), ankylosing spondylitis (AS), and systemic lupus erythematosus (SLE) are autoimmune disorders. Recent findings emphasize the importance of m6A modifications and non-coding RNAs in the biological processes underlying rheumatic diseases.

Results: This review elucidates the fundamental concept of m6A modification and the associated research methodologies. Subsequently, it systematically consolidates modern knowledge on the influence of m6A regulators and m6A modification-related ncRNAs on rheumatic diseases, incorporating perspectives on traditional Chinese medicine interventions.

Conclusions: Offering a comprehensive overview of m6A-related ncRNAs in the context of rheumatic diseases, this review proposes new therapeutic avenues by targeting m6A modification pathways.

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来源期刊
Inflammation Research
Inflammation Research 医学-免疫学
CiteScore
9.90
自引率
1.50%
发文量
134
审稿时长
3-8 weeks
期刊介绍: Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.
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