迷走神经催产素受体是食道运动和功能所必需的。

IF 6.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Mohammed Asker, Jean-Philippe Krieger, Ivana Maric, Emre Bedel, Jenny Steen, Stina Börchers, Yuxiang Wen, Francesco Longo, Patrik Aronsson, Michael Winder, Robert P Doyle, Matthew R Hayes, Karolina P Skibicka
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引用次数: 0

摘要

催产素在生殖生理中起着关键作用,但最近因其参与调节摄食行为而引起了人们的兴趣。迷走神经参与摄食行为的控制,以及其他胃肠功能。催产素受体(OTR)在迷走神经上表达,但其作用尚不清楚。在此,我们评估了迷走神经OTR对雄性和雌性大鼠食物摄入和体重控制的贡献。病源性敲除迷走神经OTR导致雄性大鼠体重和食物摄入量减少。迷走神经中OTR的缺失也导致男性运动活动受到抑制,而女性运动活动过度。重要的是,迷走神经OTR基因敲除的大鼠,而不是对照组,在敲除后4周开始表现出显著升高的死亡率,其中雄性受到的影响尤为严重。死亡发生在大量进食之后,并伴有口腔和食道中食物的异常存在,表明因误吸或气道中食物而死亡,并表明迷走神经OTR在上胃肠道运动中起关键作用。此外,体内实验显示食道转运受损。体外实验结果表明,催产素有助于食管下括约肌收缩。我们的研究结果证明了催产素系统的关键作用:迷走神经OTR在食道运输和吞咽中的重要功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vagal oxytocin receptors are necessary for esophageal motility and function.

Oxytocin plays a key role in reproductive physiology but has recently garnered interest for its involvement in modulating feeding behavior. The vagus nerve contributes to feeding behavior control, as well as other gastrointestinal functions. Oxytocin receptors (OTR) are expressed on the vagus, but their role is poorly understood. Herein, we evaluated the contribution of the vagal OTR to food intake and body weight control in male and female rats. Virogenetic knockdown of vagal OTR resulted in reduced body weight and food intake in male rats. Loss of OTR in the vagus also resulted in suppressed locomotor activity in males but hyperactivity in females. Importantly, rats with vagal OTR knockdown, but not controls, exhibited a significantly elevated mortality rate starting 4 weeks after knockdown, with males being disproportionately affected. Mortality followed large eating bouts and was accompanied by abnormal presence of food in the mouth and esophagus, suggesting death by aspiration or food in the airways and suggesting a crucial role of vagal OTR in upper gastrointestinal tract motility. Furthermore, in vivo experiments revealed impaired esophageal transit. Ex vivo findings indicated oxytocin's contribution to lower esophageal sphincter contraction. Our findings demonstrated a critical role for the oxytocin system: essential function of vagal OTR for esophageal transit and swallowing.

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来源期刊
JCI insight
JCI insight Medicine-General Medicine
CiteScore
13.70
自引率
1.20%
发文量
543
审稿时长
6 weeks
期刊介绍: JCI Insight is a Gold Open Access journal with a 2022 Impact Factor of 8.0. It publishes high-quality studies in various biomedical specialties, such as autoimmunity, gastroenterology, immunology, metabolism, nephrology, neuroscience, oncology, pulmonology, and vascular biology. The journal focuses on clinically relevant basic and translational research that contributes to the understanding of disease biology and treatment. JCI Insight is self-published by the American Society for Clinical Investigation (ASCI), a nonprofit honor organization of physician-scientists founded in 1908, and it helps fulfill the ASCI's mission to advance medical science through the publication of clinically relevant research reports.
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