阿尔茨海默病脑功能梯度的半球侧化改变。

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-22 DOI:10.1177/13872877251339761
Hao Liu, Yunfei Li, Zheng Sun, Xiaoyu Xu, Bicong Yan, Yuehua Li, Xiaohu Zhao
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引用次数: 0

摘要

人类大脑在结构、功能和生化领域表现出固有的半球不对称性。虽然皮层梯度为理解大脑网络组织提供了一个多尺度框架,但它们在阿尔茨海默病(AD)中的半球分化仍未被探索。目的研究阿尔茨海默病连续体的半球间梯度偏侧模式,并评估其临床相关性。方法对45例正常人(NC)、45例轻度认知障碍患者(MCI)和45例AD患者静息状态fMRI数据进行梯度网络处理。在这些组之间进行了平均梯度值的半球间比较。定义了17个网络的侧化指数(L值),并使用单因素方差分析分析三组之间的差异。此外,网络L值与认知得分之间的相关性进行了检验。结果snc和MCI被试在第二梯度中表现出梯度值的左偏化。相反,AD患者表现出半球间偏侧的丧失。值得注意的是,AD患者表现出默认模式网络(DMN)和控制网络的侧化减少。DMN侧化程度与认知功能显著正相关。结论阿尔茨海默病患者在梯度网络中表现出偏侧性减弱。定量梯度侧度可以作为早期AD检测和治疗监测的多模式生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altered hemispheres lateralization of brain functional gradients in Alzheimer's disease.

BackgroundThe human brain demonstrates intrinsic hemispheric asymmetry across structural, functional, and biochemical domains. While cortical gradients provide a multiscale framework for understanding brain network organization, their hemispheric divergence in Alzheimer's disease (AD) remains unexplored.ObjectiveTo characterize interhemispheric gradient lateralization patterns across the AD continuum and evaluate their clinical correlates.MethodsResting-state fMRI data of 45 normal controls (NC), 45 patients with mild cognitive impairment (MCI), and 45 patients with AD underwent gradient networks processing. Interhemispheric comparisons of mean gradient values were conducted across these groups. A lateralization index (L value) was defined for 17 networks, and differences among the three groups were analyzed using one-way ANOVA. Additionally, correlations between network L values and cognitive scores were examined.ResultsNC and MCI participants exhibited left lateralization of gradient values in the second gradient. In contrast, AD patients showed a loss of interhemispheric lateralization. Notably, AD patients demonstrated reduced lateralization in default mode network (DMN) and control network. The degree of lateralization in DMN was significantly positively correlated with cognitive function.ConclusionsOur findings indicated that patients with AD demonstrated a diminished lateralization in gradient networks. Quantifying gradient laterality may serve as a multimodal biomarker for early AD detection and therapeutic monitoring.

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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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