EBV在弥漫性大b细胞淋巴瘤发病中的作用。

3区医学 Q2 Medicine

Current topics in microbiology and immunology Pub Date : 2025-05-22 DOI:10.1007/82_2025_296

Niklas Gebauer, Sophia S Wang

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引用次数: 0

摘要

DLBCL有多种确定的危险因素；这些风险因素具有共同的生物学基础，通常会导致免疫功能障碍，从免疫抑制到慢性炎症。EBV是DLBCL的一个确定的危险因素，大约10%的DLBCL是EBV阳性。EBV是一种普遍存在的感染，因此，在免疫功能低下的人群中，按年龄或医学定义，EBV阳性dlbcl出现。本章综述EBV阳性DLBCL的分类、流行病学、临床、病理和分子特征，并讨论EBV在淋巴瘤肿瘤发生中的作用。我们进一步讨论了针对NFκB通路和其他靶点的现有和新的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of EBV in the Pathogenesis of Diffuse Large B-Cell Lymphoma.

There are multiple established risk factors for DLBCL; these risk factors share an underlying biology, which generally cause immune dysfunction, spanning immunosuppression to chronic inflammation. EBV is an established risk factor for DLBCL and approximately 10% of DLBCLs are EBV-positive. EBV is a ubiquitous infection, and it is thus among populations that are immunocompromised, by age or medically defined, where EBV-positive DLBCLs arise. In this chapter, we review the current classification, epidemiology, clinical, pathology, and molecular characteristics of EBV-positive DLBCL, and discuss the role of EBV in lymphoma tumorigenesis. We further discuss current and novel treatments aimed at the NFκB pathway and other targets.

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来源期刊

Current topics in microbiology and immunology 医学-免疫学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.