Gilles Naeije, Christian Georgiev, Pierre Cabaraux, Mathieu Bourguignon
{"title":"小脑灰质体积可预测弗里德赖希共济失调患者小脑tDCS的疗效。","authors":"Gilles Naeije, Christian Georgiev, Pierre Cabaraux, Mathieu Bourguignon","doi":"10.1016/j.clinph.2025.2110744","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine the impact of cerebellar anatomy on ctDCS efficacy in individuals with Friedreich ataxia (FA).</p><p><strong>Methods: </strong>We included 24 FA patients (mean age 31 ± 14 years) and 24 age- and sex-matched healthy controls. Patients underwent a 5-day ctDCS intervention, with cerebellar motor and non-motor symptoms assessed using the Scale for the Assessment and Rating of Ataxia (SARA) and the Cerebellar Cognitive Affective Syndrome Scale (CCAS-S), before and after stimulation. MRI was used to measure cerebellar gray matter volume, superior cerebellar peduncle (SCP) diameter, and skin-to-cerebellum distance. Stepwise linear regression analyses examined predictors of motor and cognitive improvements following ctDCS.</p><p><strong>Results: </strong>FA patients exhibited significantly reduced cerebellar gray matter volume compared to controls (p = 0.024) after intracranial volume correction, skin-to-cerebellum distance did not differ between groups (p = 0.11). Stepwise linear regression analysis disclosed that the anterior cerebellar gray matter volume was a significant predictor of SARA improvement (β = -0.18, p < 0.001) and the posterior cerebellar gray matter volume of CCAS-S improvement (β = -0.13, p 0.023). Neither SCP diameter nor skin-to-cerebellum distance significantly impacted ctDCS efficacy.</p><p><strong>Conclusion: </strong>Cerebellar gray matter volume is associated to ctDCS-induced symptoms improvements in FA.</p><p><strong>Significance: </strong>These findings suggest that cerebellar gray matter volume influences ctDCS responsiveness.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2110744"},"PeriodicalIF":3.7000,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cerebellar grey matter volume predicts cerebellar tDCS efficacy in individuals with Friedreich ataxia.\",\"authors\":\"Gilles Naeije, Christian Georgiev, Pierre Cabaraux, Mathieu Bourguignon\",\"doi\":\"10.1016/j.clinph.2025.2110744\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the impact of cerebellar anatomy on ctDCS efficacy in individuals with Friedreich ataxia (FA).</p><p><strong>Methods: </strong>We included 24 FA patients (mean age 31 ± 14 years) and 24 age- and sex-matched healthy controls. Patients underwent a 5-day ctDCS intervention, with cerebellar motor and non-motor symptoms assessed using the Scale for the Assessment and Rating of Ataxia (SARA) and the Cerebellar Cognitive Affective Syndrome Scale (CCAS-S), before and after stimulation. MRI was used to measure cerebellar gray matter volume, superior cerebellar peduncle (SCP) diameter, and skin-to-cerebellum distance. Stepwise linear regression analyses examined predictors of motor and cognitive improvements following ctDCS.</p><p><strong>Results: </strong>FA patients exhibited significantly reduced cerebellar gray matter volume compared to controls (p = 0.024) after intracranial volume correction, skin-to-cerebellum distance did not differ between groups (p = 0.11). Stepwise linear regression analysis disclosed that the anterior cerebellar gray matter volume was a significant predictor of SARA improvement (β = -0.18, p < 0.001) and the posterior cerebellar gray matter volume of CCAS-S improvement (β = -0.13, p 0.023). Neither SCP diameter nor skin-to-cerebellum distance significantly impacted ctDCS efficacy.</p><p><strong>Conclusion: </strong>Cerebellar gray matter volume is associated to ctDCS-induced symptoms improvements in FA.</p><p><strong>Significance: </strong>These findings suggest that cerebellar gray matter volume influences ctDCS responsiveness.</p>\",\"PeriodicalId\":10671,\"journal\":{\"name\":\"Clinical Neurophysiology\",\"volume\":\" \",\"pages\":\"2110744\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neurophysiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.clinph.2025.2110744\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.clinph.2025.2110744","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Cerebellar grey matter volume predicts cerebellar tDCS efficacy in individuals with Friedreich ataxia.
Objective: To determine the impact of cerebellar anatomy on ctDCS efficacy in individuals with Friedreich ataxia (FA).
Methods: We included 24 FA patients (mean age 31 ± 14 years) and 24 age- and sex-matched healthy controls. Patients underwent a 5-day ctDCS intervention, with cerebellar motor and non-motor symptoms assessed using the Scale for the Assessment and Rating of Ataxia (SARA) and the Cerebellar Cognitive Affective Syndrome Scale (CCAS-S), before and after stimulation. MRI was used to measure cerebellar gray matter volume, superior cerebellar peduncle (SCP) diameter, and skin-to-cerebellum distance. Stepwise linear regression analyses examined predictors of motor and cognitive improvements following ctDCS.
Results: FA patients exhibited significantly reduced cerebellar gray matter volume compared to controls (p = 0.024) after intracranial volume correction, skin-to-cerebellum distance did not differ between groups (p = 0.11). Stepwise linear regression analysis disclosed that the anterior cerebellar gray matter volume was a significant predictor of SARA improvement (β = -0.18, p < 0.001) and the posterior cerebellar gray matter volume of CCAS-S improvement (β = -0.13, p 0.023). Neither SCP diameter nor skin-to-cerebellum distance significantly impacted ctDCS efficacy.
Conclusion: Cerebellar gray matter volume is associated to ctDCS-induced symptoms improvements in FA.
Significance: These findings suggest that cerebellar gray matter volume influences ctDCS responsiveness.
期刊介绍：
As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology.
Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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