原发性胆管炎的全球流行病学:一项最新的系统综述和荟萃分析。

IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Jarell Jie-Rae Tan, Ambrose Hon Lam Chung, Jing Hong Loo, Joo Wei Ethan Quek, Sagar Sharma, Corrine Lee Singh, Roe Xin Jacqueline Yap, Wei Xuan Tay, Matthew K Smith, Ellina Lytvyak, Andrew Mason, Aldo J Montano-Loza, Yu Jun Wong
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引用次数: 0

摘要

背景与目的:原发性胆道胆管炎(PBC)的流行病学表现出显著的地理差异。我们的目标是提供1976年至2024年PBC患病率和发病率的全球和时间趋势的最新估计。方法:我们系统地检索了三个电子数据库,从建立到2024年8月20日,包括所有报道PBC发病率或患病率的研究。我们关注的结果是PBC的患病率和发病率。按研究类型、研究期间、地理区域、性别、人类发展指数(HDI)、诊断方法和纬度进行亚组分析。采用meta回归分析PBC患病率和发病率的时间趋势。研究方案已在PROSPERO注册(CRD42024595102)。结果:共纳入了59项研究,涵盖了25个国家的3.81亿参与者和129,455名PBC患者。在低偏倚风险的基于人群的研究中,PBC的全球总患病率为每10万人18.1例(95% CI: 14.6-22.0, I2=99.9%, 55项研究)。PBC的发病率为1.8 / 100,000人年(95% CI: 1.5-2.3, I2=99.6%, 46项研究)。在纬度较高、人类发展指数较高的国家、美国和女性中,PBC患病率较高。随着时间的推移,全球PBC患病率呈上升趋势,其中西太平洋地区的PBC患病率上升幅度最大。结论:PBC患病率的上升代表了西太平洋地区日益增长的医疗负担。纬度与PBC患病率之间的正相关关系需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Global Epidemiology of Primary Biliary Cholangitis: An Updated Systematic Review and Meta-analysis.

Background & aims: Primary biliary cholangitis (PBC) demonstrates significant geographical variability in its epidemiology. We aim to provide an updated estimate on the global and temporal trends of the prevalence and incidence of PBC from 1976 to 2024.

Methods: We systematically searched three electronic databases from inception to August 20, 2024, to include all studies reporting the incidence or prevalence of PBC. The outcomes of interest were the prevalence and incidence of PBC. Subgroup analysis was performed by study type, study period, geographical region, sex, Human Development Index, method of diagnosis, and latitude. The temporal trend of PBC prevalence and incidence was analyzed using meta-regression. The study protocol was registered with PROSPERO (CRD42024595102).

Results: A total of 59 studies, encompassing 381 million participants and 129,455 patients with PBC across 25 countries were included. The pooled global prevalence of PBC was 18.1 cases per 100,000 people (95% confidence interval, 14.6-22.0; I2 = 99.9%; 55 studies) among population-based studies with low risk of bias. The incidence rate of PBC was 1.8 per 100,000 person-years (95% confidence interval, 1.5-2.3; I2 = 99.6%; 46 studies). PBC prevalence was higher in countries with higher latitude, higher Human Development Index, in America and among the female sex. Global prevalence of PBC has increased over time, with the Western Pacific region experiencing the greatest rise in PBC prevalence over time.

Conclusion: The rising prevalence of PBC represents a growing healthcare burden in Western Pacific region. The association between latitude and PBC prevalence requires further studies.

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来源期刊
CiteScore
16.90
自引率
4.80%
发文量
903
审稿时长
22 days
期刊介绍: Clinical Gastroenterology and Hepatology (CGH) is dedicated to offering readers a comprehensive exploration of themes in clinical gastroenterology and hepatology. Encompassing diagnostic, endoscopic, interventional, and therapeutic advances, the journal covers areas such as cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion. As a peer-reviewed publication, CGH features original articles and scholarly reviews, ensuring immediate relevance to the practice of gastroenterology and hepatology. Beyond peer-reviewed content, the journal includes invited key reviews and articles on endoscopy/practice-based technology, health-care policy, and practice management. Multimedia elements, including images, video abstracts, and podcasts, enhance the reader's experience. CGH remains actively engaged with its audience through updates and commentary shared via platforms such as Facebook and Twitter.
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