从嗜酸性链霉菌中分离的嗜远杀素类似物作为膜-囊泡调节的天然产物。

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI:10.1248/cpb.c25-00197

Aya Yoshimura, Ryusuke Nakada, Toshiyuki Wakimoto

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引用次数: 0

摘要

从嗜杀链霉菌中分离到4个杀远菌素类似物，并分离到杀远菌素B3。质谱和核磁共振结合分析了它们的结构，发现它们是新分离的代谢产物。已知的代谢物远杀菌素A2和B3对嗜根Kocuria和枯草芽孢杆菌的抑菌活性较弱。值得注意的是，多沃氏伯克霍尔德菌的膜囊泡调节了嗜杀葡萄球菌中嗜杀葡萄球菌类似物的产生水平，上调了嗜杀葡萄球菌的生物合成，但下调了随后的乙酰化步骤。

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Teleocidin Analogs Isolated from Streptomyces eurocidicus as Membrane-Vesicle-Regulated Natural Products.

Four teleocidin analogs were isolated from Streptomyces eurocidicus, along with teleocidin B3. A combination of MS and NMR analyses elucidated their structures, revealing teleocidin A2 acetate and teleocidin B3 acetate as newly isolated metabolites. Teleocidins A2 and B3, known metabolites, exhibited weak antibacterial activities against Kocuria rhizophila and Bacillus subtilis. Notably, membrane vesicles of Burkholderia multivorans modulated the production levels of teleocidin analogs in S. eurocidicus, upregulating teleocidin biosynthesis but downregulating the subsequent acetylation step.

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.