早期羟基酪醇的管理延长寿命和延缓衰老秀丽隐杆线虫。

IF 5.7 2区生物学 Q1 BIOLOGY

Biology Direct Pub Date : 2025-05-21 DOI:10.1186/s13062-025-00634-x

Nannan Du, Lishuo Song, Ruigang Yang, Kexin Liu, Zubiao Niu, Zhanfeng Zhang, Qiang Sun

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引用次数: 0

摘要

背景：本研究以秀丽隐杆线虫（C. elegans）为模型生物，探讨羟酪醇（hydroxytyrosol， HT）的抗衰老作用及其机制。结果：研究结果表明，在成年后第一天给药时，HT显著延长秀丽隐杆线虫的寿命，同时改善其功能表现（运动和咽功能）和抗氧化能力（D1）。然而，当在成年期第三天或之后开始治疗时，其疗效减弱（D3）。HT通过类似于skin -1调节氧化应激途径的机制延长寿命。结论：给药时机是影响抗氧化化合物抗衰老效果的重要因素。

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Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans.

Background: This study employs Caenorhabditis elegans (C. elegans) as a model organism to explore the anti-aging effects of hydroxytyrosol (HT) and its underlying mechanisms.

Results: The findings reveal that HT significantly extends the lifespan of C. elegans while improving their functional performance (motility and pharyngeal function), and antioxidant capacity when administered on the first day of adulthood (D1). However, its efficacy diminishes when treatment begins on or after the third day of adulthood (D3). HT prolongs lifespan through a mechanism akin to that of skn-1 modulating the oxidative stress pathway.

Conclusions: This study suggests that the administration timing is an important factor for of anti-oxidation compounds to be effective in counteracting aging.

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来源期刊

Biology Direct 生物-生物学

CiteScore

6.40

自引率

10.90%

发文量

审稿时长

7 months

期刊介绍： Biology Direct serves the life science research community as an open access, peer-reviewed online journal, providing authors and readers with an alternative to the traditional model of peer review. Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in subject areas currently identified as those most conducive to the open review approach, primarily those with a significant non-experimental component.