儿童期癫痫消退后年轻人的认知结局。

IF 8.1 1区医学 Q1 CLINICAL NEUROLOGY

Annals of Neurology Pub Date : 2025-05-22 DOI:10.1002/ana.27258

Jacob Megreli, Leo Arkush, Estela Derazne, Arnon Afek, Gilad Twig, Bruria Ben-Zeev, Jaana Ahonniska Assa, Gali Heimer

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引用次数: 0

摘要

儿童期自限性癫痫很常见，被认为是良性的。我们的目的是确定儿童时期经历癫痫并随后无癫痫发作和未用药的年轻人的认知功能是否与一般人群不同。我们报告了一项基于人群的横断面研究，包括2124871名年龄在16-19岁的男性和女性。最后一次癫痫发作后bbbb5年和bbbb2年未服用抗癫痫药物（n = 3,452）的参与者认知功能较低的比值比（OR）为1.44(95%置信区间[CI] = 1.24-1.68, p

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Cognitive Outcome in Young Adults after Resolution of Epilepsy in Childhood.

Self-limited epilepsies of childhood are common and were considered benign. We aim to determine whether cognitive function in young adults who experienced epilepsy as children and are subsequently seizure-free and unmedicated differ from the general population. We report on a cross-sectional population-based study including 2,124,871 men and women aged 16-19 years. Participants > 5 years following the last seizure and > 2 years without anti-seizure medication (n = 3,452) had an odds ratio (OR) of having low cognitive function of 1.44 (95% confidence interval [CI] = 1.24-1.68, p < 0.001) using a multinominal regression model. Our results underscore the need to avoid the term "benign" in the classification of childhood epilepsies. ANN NEUROL 2025.

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.