凝血因子IX：结构、功能和调控

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

IUBMB Life Pub Date : 2025-05-22 DOI:10.1002/iub.70024

Lacramioara Ivanciu, Rodney M. Camire

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引用次数: 0

摘要

凝血因子IX通过生成因子Xa在凝血的内在途径中起着至关重要的作用，最终导致凝血酶的形成。在过去的50年里，广泛的研究加深了我们对因子IX的生物学、生理学、病理学、生物化学和分子遗传学的理解。这些丰富的知识揭示了因子IX基因和蛋白是如何进化的，因子IX是如何被调节的，它在凝血级联中是如何起作用的，以及结构变化是如何影响其功能的。在这篇综述中，我们将总结目前关于因子IX的生物学知识，重点是其结构-功能关系，基因结构和调控。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Blood Coagulation Factor IX: Structure, Function, and Regulation

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Blood Coagulation Factor IX: Structure, Function, and Regulation

Blood coagulation factor IX plays a crucial role in the intrinsic pathway of coagulation by generating factor Xa, ultimately leading to thrombin formation. Over the past 50 years, extensive research has deepened our understanding of the biology, physiology, pathology, biochemistry, and molecular genetics of factor IX. This wealth of knowledge has revealed how the factor IX gene and protein evolved, how factor IX is regulated, how it functions within the coagulation cascade, and how structural changes affect its function. In this review, we will summarize current knowledge on the biology of factor IX, with a focus on its structure–function relationships, gene structure, and regulation.

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来源期刊

IUBMB Life 生物-生化与分子生物学

CiteScore

10.60

自引率

0.00%

发文量

109

审稿时长

4-8 weeks

期刊介绍： IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.