ESCRT III通过抑制激酶1导致人类细胞Agnps细胞毒性调控溶酶体核周聚集（Adv. Mater.）。接口10/2025)

IF 4.3 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Interfaces Pub Date : 2025-05-22 DOI:10.1002/admi.202570030

Tiantian Liu, Aiguo Xie, Chao Xing, RuiZhe He, Wei Ni, Yinbo Peng, Peng Xu, Yong Fang

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引用次数: 0

摘要

在2400944号文章中，彭银波、徐鹏、方勇等研究了纳米银粒子（AgNPs）如何通过破坏溶酶体转运，导致溶酶体核周聚集（LPC）和随后的细胞凋亡，从而诱导人成纤维细胞的细胞毒性。该研究强调了Kinesin 1和ESCRT III在维持溶酶体完整性方面的重要作用，并为优化AgNP治疗应用提供了见解，同时最大限度地减少不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

ESCRT III Regulates Lysosomal Perinuclear Clustering by Inhibiting Kinesin 1 Leading to Agnps Cytotoxicity in Human Cells (Adv. Mater. Interfaces 10/2025)

Silver Nanoparticles

In article 2400944, Yinbo Peng, Peng Xu, Yong Fang, and co-workers investigate how silver nanoparticles (AgNPs) induce cytotoxicity in human fibroblasts by disrupting lysosomal transport, leading to lysosomal perinuclear clustering (LPC) and subsequent apoptosis. The research highlights the essential roles of Kinesin 1 and ESCRT III in maintaining lysosomal integrity and offers insights for optimizing AgNP therapeutic applications while minimizing adverse effects.

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来源期刊

Advanced Materials Interfaces CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

8.40

自引率

5.60%

发文量

1174

审稿时长

1.3 months

期刊介绍： Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018. The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface. Advanced Materials Interfaces covers all topics in interface-related research: Oil / water separation, Applications of nanostructured materials, 2D materials and heterostructures, Surfaces and interfaces in organic electronic devices, Catalysis and membranes, Self-assembly and nanopatterned surfaces, Composite and coating materials, Biointerfaces for technical and medical applications. Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.