正炔基萘酚催化转化研究进展

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-05-19 DOI:10.1016/j.tet.2025.134726

Fatemeh Doraghi , Reza Hassanzadeh Dostkoh , Haniyeh Tavakoli , Bagher Larijani , Mohammad Mahdavi

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引用次数: 0

摘要

由于具有多个反应位点，正炔基萘酚被广泛应用于各种有机转化。这些前体可以很容易地转化为高度亲电的偏乙烯基-醌甲基（VQM）、乙烯基碳正离子或乙烯基自由基中间体，以合成一大家族的辅助手性有机化合物，包括双芳基、芳基/杂芳基和芳基/苯乙烯。从合成的角度来看，正炔基萘酚的吸引力使我们强调了这种有价值的分子在各种催化方法下的转化，如Lewis酸性、Brønsted酸性、Brønsted碱性和金属催化体系。

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Recent advances in catalytic transformations of ortho-alkynylnaphthols

Due to multiple reactive sites, ortho-alkynylnaphthols are extensively used in a diverse range of organic transformations. These precursors can be readily transformed into highly electrophilic vinylidene-quinone methide (VQM), vinyl carbocation, or vinyl radical intermediates towards the synthesis of a large family of auxiliary chiral organic compounds containing biaryls, aryl/heteroaryl and aryl/styrenes. The attractiveness of ortho-alkynylnaphthol from a synthetic point of view has led us to highlight the transformations of this valuable molecule in the presence of various catalytic methods, such as Lewis acidic, Brønsted acidic, Brønsted basic and metal catalytic systems.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.