弥合差距-从猫科动物的角度重新思考肾上腺在慢性肾脏疾病中的作用

IF 1.9 2区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Patricia Lunet Marques , Sara Galac , Luísa Mateus , Rodolfo Oliveira Leal
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引用次数: 0

摘要

慢性肾脏疾病(CKD)是家猫最常见的代谢疾病。与人类和狗不同,猫的CKD似乎具有高度复杂和多因素的病因。尽管大量的研究努力试图阐明CKD发病机制的可能途径,但对其起始和进展因素仍然缺乏了解。这些患者也缺乏治疗选择,大多数治疗计划依赖于低磷酸盐饮食、饮食蛋白质调整和并发症(如高血压)的医疗管理。在这篇综述中,我们提出下丘脑-垂体-肾上腺(HPA)轴在猫慢性肾脏疾病的发生、病理生理和进展中起核心作用。特别是肾上腺及其分泌的激素,可能在慢性肾脏疾病中起着关键作用,几乎介导了疾病的各个方面:从纤维化和肾脏损伤的建立到高血压和促炎状态的发展。通过汇编关于肾上腺激素和HPA轴影响的现有研究,我们希望强调未来可能对猫CKD的科学兴趣领域,以及猫可能作为人类医学研究模型的可能方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bridging the gap—Rethinking the role of the adrenal gland in chronic kidney disease from the feline perspective
Chronic kidney disease (CKD) is the most common metabolic disease in domestic cats. Unlike humans and dogs, CKD in cats seems to have a highly complex and multifactorial etiology. Despite great effort being poured into research trying to elucidate possible pathways for the pathogenesis of CKD, there is still a lack of understanding regarding its initiating and progression factors. There is also a lack of therapeutic options for these patients, with most treatment plans relying on a low-phosphate diet, dietary protein modification and medical management of complications (e.g. hypertension) as they arise.
In this review, we propose the hypothalamic-pituitary-adrenal (HPA) axis plays a central role in the development, pathophysiology and progression of feline chronic kidney disease. The adrenal glands and the hormones they secrete, in particular, may act as lynchpins in chronic kidney disease, mediating virtually every aspect of the disease: from the establishment of fibrosis and kidney damage to the development of hypertension and a pro-inflammatory status. By compiling the available research regarding the influence of adrenal hormones and the HPA axis, we hope to highlight possible future areas of scientific interest regarding feline CKD as well as possible aspects in which the cat may act as a model for research in human medicine.
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来源期刊
Domestic animal endocrinology
Domestic animal endocrinology 农林科学-奶制品与动物科学
CiteScore
5.50
自引率
4.80%
发文量
58
审稿时长
31 days
期刊介绍: Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors
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