双功能离子液体诱导喹啉与芳基三氮烯的C-H电化学芳基化反应

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-15 DOI:10.1021/acs.joc.5c0046010.1021/acs.joc.5c00460

Chenyu Li, Wei Xu, Bin Wang, Ziren Chen, Yu Xia, Shaofeng Wu, Weiwei Jin, Chenjiang Liu* and Yonghong Zhang*,

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引用次数: 0

摘要

研究了一种离子-液体诱导喹啉与芳基三氮烯的高效双官能团电化学C-H芳化反应。该反应利用芳基三氮烯作为稳定的芳基化试剂，离子液体作为促进剂和电解质。在温和、无金属和无氧化剂的条件下，以中等到优异的收率组装了各种芳基化喹啉-2(1H)- 1、喹啉和2-甲基二苯并[f，h]喹啉。该方案具有操作简单、官能团耐受性好、选择性好、产品衍生性好、批量和连续流工艺中克级合成实用等特点。

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Bifunctional Ionic Liquids Induced Electrochemical C–H Arylation of Quinoxalin(on)es with Aryltriazenes

An efficient bifunctional ionic-liquid-induced electrochemical C–H arylation of quinoxalin(on)es with aryltriazenes has been developed. The reaction utilizes aryltriazenes as stable arylation reagents and ionic liquids as promoter and electrolyte. Various arylated quinoxalin-2(1H)-ones, quinoxaline and 2-methyldibenzo[f,h]quinoxaline were assembled in modest to excellent yields under mild, metal- and oxidant-free conditions. The developed protocol features simple operation, good functional group tolerance, good selectivity, product derivatization, and practical gram-scale synthesis in batch and continuous-flow processes.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.