碘化钠促进全取代4-磺酰基-5-氨基吡唑衍生物的构建。

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-21 DOI:10.1021/acs.joc.5c00667

Ziru Huang,Hangjin Wu,Meiqi Geng,Jinqiang Kuang,Yongmin Ma

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引用次数: 0

摘要

在温和的条件下，通过nai介导的β-酮腈、二硫化物和肼三组分反应，合成了无过渡金属的多取代4-磺酰基-5-氨基吡唑。通过连续裂解C-O和S-S键，并将C-N和C-S键重组，构建了吡唑产物。该方法的特点是衬底范围广，无过渡金属条件温和，易于操作。

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Sodium Iodide-Promoted Construction of Fully Substituted 4-Sulfenyl-5-aminopyrazole Derivatives.

Transition-metal-free synthesis of diversely substituted 4-sulfenyl-5-aminopyrazoles was developed under mild conditions through NaI-mediated three-component reaction of β-ketonitriles, disulfides, and hydrazines. The pyrazole products were constructed via consecutive cleavage of C-O and S-S bonds and recombination of C-N and C-S bonds. The methodology features broad substrate scope, mild transition-metal-free conditions, and easy manipulation.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.