脉络膜丛扩大通过帕金森氏病的区域淋巴功能障碍增加运动严重程度

IF 6.7 1区 医学 Q1 NEUROSCIENCES
Linyu Liu, Qiang Weng, Qing Cai, Xintong Yu, Weibin Huang, Shaohua Xie, Yan Shi, Huiting Li, Yuxuan Zhang, Jianping Hu, Mengcheng Li, Guannan Chen, Ning Wang, Xiang Lin, Ying Fu, Yu Lin
{"title":"脉络膜丛扩大通过帕金森氏病的区域淋巴功能障碍增加运动严重程度","authors":"Linyu Liu, Qiang Weng, Qing Cai, Xintong Yu, Weibin Huang, Shaohua Xie, Yan Shi, Huiting Li, Yuxuan Zhang, Jianping Hu, Mengcheng Li, Guannan Chen, Ning Wang, Xiang Lin, Ying Fu, Yu Lin","doi":"10.1038/s41531-025-00971-8","DOIUrl":null,"url":null,"abstract":"<p>Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson’s disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volume, perivascular spaces (PVS), and motor symptom severity in 123 PD patients stratified by disease stage. MRI quantified CP volume and PVS, including dilated PVS (dPVS), across brain regions. CP-dPVS correlations were stronger in early-stage PD. Region-specific analyses revealed CP volume was associated with PVS in the midbrain and basal ganglia. CP-dPVS correlations emerged in midbrain, basal ganglia, and centrum semiovale. Correlation matrix and mediation analyses together confirmed that only basal ganglia dPVS was both significantly correlated with motor symptoms and served as a mediator, accounting for 30.52% of the association between CP volume and motor severity. These findings suggest that CP enlargement contributes to motor severity in PD, in part through regional glymphatic dysfunction localized to the basal ganglia.</p>","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"40 1","pages":""},"PeriodicalIF":6.7000,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease\",\"authors\":\"Linyu Liu, Qiang Weng, Qing Cai, Xintong Yu, Weibin Huang, Shaohua Xie, Yan Shi, Huiting Li, Yuxuan Zhang, Jianping Hu, Mengcheng Li, Guannan Chen, Ning Wang, Xiang Lin, Ying Fu, Yu Lin\",\"doi\":\"10.1038/s41531-025-00971-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson’s disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volume, perivascular spaces (PVS), and motor symptom severity in 123 PD patients stratified by disease stage. MRI quantified CP volume and PVS, including dilated PVS (dPVS), across brain regions. CP-dPVS correlations were stronger in early-stage PD. Region-specific analyses revealed CP volume was associated with PVS in the midbrain and basal ganglia. CP-dPVS correlations emerged in midbrain, basal ganglia, and centrum semiovale. Correlation matrix and mediation analyses together confirmed that only basal ganglia dPVS was both significantly correlated with motor symptoms and served as a mediator, accounting for 30.52% of the association between CP volume and motor severity. These findings suggest that CP enlargement contributes to motor severity in PD, in part through regional glymphatic dysfunction localized to the basal ganglia.</p>\",\"PeriodicalId\":19706,\"journal\":{\"name\":\"NPJ Parkinson's Disease\",\"volume\":\"40 1\",\"pages\":\"\"},\"PeriodicalIF\":6.7000,\"publicationDate\":\"2025-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"NPJ Parkinson's Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41531-025-00971-8\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"NPJ Parkinson's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41531-025-00971-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

脉络膜丛(CP)扩大和淋巴功能障碍与神经退行性变有关,但它们在帕金森病(PD)中的作用尚不清楚。这项回顾性横断面研究检查了123名PD患者按疾病分期分层的CP体积、血管周围间隙(PVS)和运动症状严重程度之间的关系。MRI量化脑区CP体积和PVS,包括扩张的PVS (dPVS)。CP-dPVS在早期PD中相关性更强。区域特异性分析显示CP体积与中脑和基底节区PVS相关。CP-dPVS在中脑、基底节区和半叶中央出现相关性。相关矩阵和中介分析共同证实,只有基底节区dPVS与运动症状显著相关,并发挥中介作用,占CP体积与运动严重程度相关性的30.52%。这些发现表明,CP增大有助于PD的运动严重程度,部分原因是基底神经节的区域性淋巴功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease

Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease

Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson’s disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volume, perivascular spaces (PVS), and motor symptom severity in 123 PD patients stratified by disease stage. MRI quantified CP volume and PVS, including dilated PVS (dPVS), across brain regions. CP-dPVS correlations were stronger in early-stage PD. Region-specific analyses revealed CP volume was associated with PVS in the midbrain and basal ganglia. CP-dPVS correlations emerged in midbrain, basal ganglia, and centrum semiovale. Correlation matrix and mediation analyses together confirmed that only basal ganglia dPVS was both significantly correlated with motor symptoms and served as a mediator, accounting for 30.52% of the association between CP volume and motor severity. These findings suggest that CP enlargement contributes to motor severity in PD, in part through regional glymphatic dysfunction localized to the basal ganglia.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
NPJ Parkinson's Disease
NPJ Parkinson's Disease Medicine-Neurology (clinical)
CiteScore
9.80
自引率
5.70%
发文量
156
审稿时长
11 weeks
期刊介绍: npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信